Stimulus Delivery and Response Hardware for fMRI Studies in Substance Abuse

用于药物滥用 fMRI 研究的刺激传递和响应硬件

• 批准号: 7329118
• 负责人: Stephen B. Baumann
• 金额: $ 69.9万
• 依托单位: PSYCHOLOGY SOFTWARE TOOLS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7329118
• 关键词: Addictive Behavior; Affect; Anxiety; Applications Grants; Attenuated; Award; Base of the Brain; Brain; Brain imaging; Businesses; Centers for Disease Control and Prevention (U.S.); Cigarette Smoker; Cognition; Complex; Computer software; Computers; Craniocerebral Trauma; Data; Development; Devices; Drug abuse; Emotions; Engineering; Environment; Equipment; Event; Exposure to; Family; Feedback; Fingers; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Generations; Goals; Grant; Health; Human; Image; Immersion Investigative Technique; Income; Individual; Integrated Delivery Systems; Joystick; Link; Magnetic Resonance Imaging; Maps; Marketing; Modeling; Morphologic artifacts; Movement; National Institute of Drug Abuse; Noise; Odors; Peripheral; Pharmaceutical Preparations; Phase; Plague; Predisposition; Process; Psychology; Purpose; Recording of previous events; Recruitment Activity; Request for Proposals; Research; Research Design; Research Personnel; Sales; Sensory; Signal Transduction; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Smoker; Smoking; Societies; Software Design; Software Tools; Solutions; Standards of Weights and Measures; Stimulus; Stream; Structure; Substance abuse problem; System; Tactile; Taste Perception; Techniques; Technology; Testing; Tongue; United States Food and Drug Administration; United States National Institutes of Health; Universities; Vision; Work; addiction; auditory stimulus; base; brain pathway; comparative; computerized; craving; drug of abuse; experience; grasp; improved; innovation; neuroimaging; novel strategies; programs; prototype; research and development; response; sensory stimulus; simulation; software development; tool; virtual; virtual reality

DESCRIPTION (provided by applicant): Addiction is a critical issue for our society and involves complex brain processes in which sensory stimulation and interaction with the environment are key factors for its understanding and treatment. This project proposes to develop a comprehensive family of hardware products for evoking intense sensory and experiential interaction during brain imaging studies. In particular the project will assess how the quality of the sensory experience and interaction affects brain pathways involved in craving and addiction. Specialized stimulation and control hardware will be engineered and used in fMRI studies to evaluate the added benefit of the technology. The effort involves integrating advanced technology for stimulus presentation, leading edge immersive VR technology, and fMRI based brain imaging. It will provide a comprehensive family of hardware products that can be used together or independently during fMRI studies and potentially during the course of drug abuse treatment efforts. The proposed fMRI peripheral hardware includes: 1) a stereo projector system to increase the sense of immersion; 2) an integrated dataglove with force and tactile feedback enabling grasping studies with virtual objects; 3) an odor delivery system capable of presenting multiple odors to a subject; 4) a taste delivery system capable of providing multiple tastes directly to the tongue; 5) an auditory stimulus delivery system with active noise cancellation to dramatically attenuate scanner noise; 6) a gamepad controller with joystick and buttons enabling control movement and responses during VR studies inside or outside of an MRI scanner. In addition to preliminary testing with subjects during fMRI studies of all the hardware to substantiate its effects, a comparative fMRI study with smokers will test the ability of the hardware to deliver sensory augmented VR simulations that are an improvement over the more traditional use of static images in craving studies. The business and marketing plan are conservative and based on the successful model Psychology Software Tools Inc (PST) has used in past niche market product development and marketing. The staff includes leaders in computerized experimentation, brain imaging and fMRI addiction research who have a history of working with university researchers to provide market leading technology in experimental control (E- Prime is used by over 10,000 researchers) and functional imaging systems (IFIS is installed at over 200 MRI sites). The business plan builds on the past track record that has resulted in every SBIR phase II research program being transitioned into a market leading technology with over three million dollars of commercial sales within five years. Future research by many investigators would utilize the developed technology to advance understanding of brain processes involving addiction and cognition and provide a profitable income stream to continue innovation in the growing research interface of brain, cognition and addiction. This project will conduct the scientific research and development necessary to provide a comprehensive family of hardware products for effectively and reliably evoking intense sensory and experimental interaction during fMRI brain imaging. Future scientific research efforts made possible or furthered by the availability of these tools will advance the understanding of the brain processes related to addictive behavior and cognition. This understanding will be used to assess and treat key societal substance abuse problems which have become a plague upon the health of our nation, affecting millions of individuals and defying current solutions.

描述(由申请人提供)：成瘾是我们社会的一个关键问题，涉及复杂的大脑过程，其中感觉刺激和与环境的相互作用是理解和治疗成瘾的关键因素。该项目建议开发一系列全面的硬件产品，用于在脑成像研究中唤起强烈的感觉和经验交互。特别是，该项目将评估感觉体验和互动的质量如何影响与渴望和成瘾有关的大脑通路。专门的刺激和控制硬件将被设计并用于功能磁共振研究，以评估该技术的额外好处。这项努力涉及整合用于刺激呈现的先进技术、尖端沉浸式VR技术和基于功能磁共振成像的大脑成像。它将提供一个全面的硬件产品系列，可以在功能磁共振研究期间一起使用或单独使用，并可能在药物滥用治疗过程中使用。拟议的功能磁共振外围硬件包括：1)增加沉浸感的立体声投影仪系统；2)集成了力和触觉反馈的数据手套，能够用虚拟对象进行研究；3)能够向受试者呈现多种气味的气味输送系统；4)能够直接向舌头提供多种味道的味觉输送系统；5)具有主动消噪功能的听觉刺激输送系统，可以显著降低扫描仪的噪音；6)游戏手柄控制器，带有操纵杆和按钮，可以控制在磁共振扫描仪内外进行VR研究时的移动和反应。除了在所有硬件的功能磁共振研究期间对受试者进行初步测试以证实其效果外，一项与吸烟者进行的比较功能磁共振研究还将测试硬件提供感觉增强VR模拟的能力，这比在渴望研究中使用静态图像的更传统的使用方式有所改进。业务和营销计划是保守的，并基于心理学软件工具公司(PST)在过去的利基市场产品开发和营销中使用的成功模式。这些员工包括计算机化实验、脑成像和功能磁共振成瘾研究领域的领导者，他们有与大学研究人员合作的历史，在实验控制(超过10,000名研究人员使用E-Prime)和功能成像系统(IFIS安装在200多个MRI站点)方面提供市场领先的技术。该商业计划建立在过去的记录基础上，这些记录导致每个SBIR第二阶段研究计划都转变为市场领先的技术，在五年内商业销售额超过300万美元。许多研究人员未来的研究将利用开发的技术来促进对涉及成瘾和认知的大脑过程的理解，并提供一个有利可图的收入来源，以继续在大脑、认知和成瘾日益增长的研究界面上进行创新。该项目将进行必要的科学研究和开发，以提供全面的硬件产品系列，在功能磁共振成像过程中有效和可靠地唤起强烈的感觉和实验互动。这些工具的出现使未来的科学研究工作成为可能，或进一步推动了对与成瘾行为和认知相关的大脑过程的理解。这一认识将被用来评估和治疗关键的社会药物滥用问题，这些问题已经成为我国健康的一大祸害，影响着数百万人，并无视目前的解决办法。