Neural Aspects of Tinnitus

耳鸣的神经方面

• 批准号: 7349928
• 负责人: RICHARD J SALVI
• 金额: $ 33.08万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349928
• 关键词: Acoustics; Affect; Agonist; American; Aminobutyric Acid; Aminobutyric Acids; Animal Model; Animals; Auditory; Auditory area; Auditory system; Behavioral; Behavioral Model; Biological; Brain; Brain imaging; Butyric Acid; Butyric Acids; Chronic; Dose; Effectiveness; Elderly; Electrodes; GABA Agonists; Generations; Goals; Human; Implant; Individual; Measures; Noise; Noise Induced Tinnitus; Output; Pattern; Peripheral; Pharmaceutical Preparations; Pharmacotherapy; Polydipsia; Positron-Emission Tomography; Potassium Channel; Potassium Channel Blockers; Rattus; Recovery; Role; Schedule; Site; Subjective Tinnitus; System; Techniques; Testing; Time; Tinnitus; Up-Regulation; Vigabatrin; Yang; awake; behavior measurement; conditioning; design; drug development; gamma-Aminobutyric Acid; insight; neurophysiology; prepulse inhibition; relating to nervous system; research study; salicylate; sound

DESCRIPTION (provided by applicant): The overall goals of this project are to (1) obtain behavioral estimates of tinnitus induced by salicylate and acoustic overstimulation and measure the time course and the pitch of the tinnitus in individual animals, (2) identify the changes in neural activity (single unit activity, local field potentials) in the auditory cortex of awake rats using16 channel recording electrodes and (3) determine how the time course and pattern of neural activity correlate with behavioral measures of the pitch and time course of tinnitus, (4) determine if the behavioral and neurophysiological measures of salicylate induced tinnitus and noise-induced tinnitus can be suppressed by NS1883, a potassium channel agonist that has shown promise in suppressing salicylate-induced tinnitus. Two behavioral techniques, SIPAC and GPIAS, will be used to independently confirm the time course and pitch of the tinnitus. Spontaneous and sound evoked neural activity will be assessed in awake animals using chronically implanted 16-channel electrode arrays. The project will significantly advance our understanding of the time course and pitch of noise and drug induced tinnitus in an animal model, aid in identifying the key neurophysiological changes in the auditory cortex that are associated with tinnitus, and evaluate the effectiveness of a potassium channel agonist in suppressing salicylate and noise-induced tinnitus.

描述（由申请人提供）：该项目的总体目标是（1）获得由水杨酸盐和声学过度刺激引起的耳鸣的行为估计值，并测量单个动物中耳鸣的时间过程以及耳鸣的音调，（2）确定神经活动的变化（单位活动，局部现场电位，使用了16个单位活动）的变化，并确定了16频道的录音（局部现场电位）。神经活动与耳鸣的音高和时间过程的行为度量相关，（4）确定水杨酸盐的行为和神经生理学测量是否可以通过NS1883抑制降水剂，这表明在抑制了抑制盐酸化的tinitus tinitus tinitus tinitus tinitus。两种行为技术（SIPAC和GPIAS）将用于独立确认耳鸣的时间过程和音高。将使用长期植入的16通道电极阵列在清醒动物中评估自发和声音诱发的神经活动。该项目将显着提高我们对动物模型中噪声和药物诱导的鸣鸣的时间过程和俯仰的理解，有助于识别与耳鸣相关的听觉皮层中关键的神经生理学变化，并评估钾通道激动剂在抑制水杨酸酯和噪声诱导的Tinnnitus方面的有效性。