Growth factors and their effect on microRNAs and transcription factors in tubulointerstitial fibrosis in diabetes

生长因子及其对糖尿病肾小管间质纤维化中 microRNA 和转录因子的影响

• 批准号: nhmrc : 526663
• 负责人: Dr Phillip Kantharidis
• 金额: $ 32.69万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/growth-factors-effect-fibrosis-diabetes/76403
• 关键词: Growth; factors; their; effect; microRNAs

A common cause of kidney disease is diabetes and is partly related to increased expression and action of growth factors such as CTGF. These factors promote the deposition of scar tissue in the kidney by acting on a novel class of intracellular regulator molecules called microRNAs, to change the cell's characteristics such that cells begin laying down excess collagen. This proposal will focus on how growth factors act on microRNAs and the role of microRNAs in diabetic kidney disease.

肾脏疾病的常见原因是糖尿病，并且部分与生长因子如CTGF的表达和作用增加有关。这些因子通过作用于一种称为microRNA的新型细胞内调节分子，改变细胞的特性，使得细胞开始沉积多余的胶原蛋白，从而促进瘢痕组织在肾脏中的沉积。该提案将重点关注生长因子如何作用于microRNA以及microRNA在糖尿病肾病中的作用。