Role of growth and transcription factors in tubulointerstitial injury in diabetes

生长因子和转录因子在糖尿病肾小管间质损伤中的作用

• 批准号: nhmrc : 367620
• 负责人: Dr Phillip Kantharidis
• 金额: $ 30.27万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-growth-transcription-injury-diabetes/97535
• 关键词: Role; growth; transcription; factors; tubulointerstitial

Progressive kidney disease occurs as a result of a range of molecular and cellular pathways. One of the commonest causes of kidney disease is diabetes and this appears to be partly related to increased expression and action of certain growth factors such as CTGF. These factors promote the deposition of scar tissue in the kidney and one of the ways these promote this scarring is to change a cell s behaviour so that it now lays down collagen. This proposal will not only focus on how CTGF promotes scarring but will explore 2 novel factors called Snail and Slug which can act directly on particular genes such as CTGF to inhibit these deleterious effects. By further characterising these pathways involving Snail, Slug and CTGF in the kidney it will be possible to generate new targets and therapies for various forms of progressive kidney disease including diabetic kidney disease.

进行性肾脏疾病的发生是一系列分子和细胞途径的结果。肾脏疾病最常见的原因之一是糖尿病，这似乎在一定程度上与某些生长因子的表达和作用增加有关，如CTGF。这些因素促进了肾脏中疤痕组织的沉积，其中一种促进疤痕形成的方法是改变细胞S的行为，使其现在形成胶原蛋白。这项提案不仅关注CTGF如何促进瘢痕形成，还将探索两种新的因子，即蜗牛和鼻涕，它们可以直接作用于特定的基因，如CTGF，以抑制这些有害影响。通过进一步表征这些涉及蜗牛、鼻涕虫和CTGF在肾脏中的通路，将有可能为包括糖尿病肾病在内的各种形式的进行性肾脏疾病创造新的靶点和治疗方法。