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How insulin and the insulin-like growth factors bind to their receptors - the key role of the ?-chain C-terminal helix

How insulin and the insulin-like growth factors bind to their receptors - the key role of the ?-chain C-terminal helix
胰岛素和胰岛素样生长因子如何与其受体结合——β链C端螺旋的关键作用
批准号:
nhmrc : 1005896
负责人:
A/Pr Michael Lawrence
金额:
$50.19万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

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中文摘要
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英文摘要
Cancer, Alzheimer’s disease and diabetes are three of the most important health issues facing Australia. Aberrant signalling into the cell interior by the related insulin receptor and Type 1 insulin-like growth factor receptor is implicated in all three of these disease states. Our research is aimed at understanding how these signalling events occur at the atomic level of detail – such knowledge has the potential to contribute to the development of novel therapeutics aimed at treating these diseases.
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会议论文
Conologues: Ultra-fast-acting therapeutic insulins based on cone snail venom insulin principles
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    乔洁
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