CIRCADIAN RHYTHMS, SLEEP RESTRICTION AND METABOLIC AGING

睡眠不足对年轻人和老年人来说都是一个主要的健康和安全问题。全国民调 这表明，超过四分之一的18-84岁的成年人每晚睡眠时间少于7小时， 15%报告每晚睡眠少于6小时。与此相关的警觉性和表现能力的缺陷 睡眠不足会导致更大的车祸、家庭和工作场所事故的风险， 睡眠中的工作失误。睡眠不足也会对生活质量产生负面影响， 对易怒情绪和动力都有影响急性睡眠剥夺研究的证据表明， 老年人对睡眠不足的反应可能与年轻人不同，但研究比较了老年人对睡眠不足的反应。 尚未对老年人和年轻人进行长期睡眠限制。 在这里，我们建议调查4周的慢性白天睡眠不足的后果 老年人（55-70岁）和年轻人（18-30岁）的警觉性和表现。受试者将被安排睡眠， 相当于在强制脱髓鞘方案中每24小时5小时，以便我们可以研究 在4周睡眠期间，昼夜节律和觉醒对警觉性和表现的贡献 限制.我们将使用主观和客观的方法来评估每次清醒时的警觉性， 受试者将每天执行一系列任务， 限制认知吞吐量，持续注意力，反应时间，动机，情绪和短期 记忆我们的研究设计将使我们能够独立地评估一天中的时间（昼夜节律相位）的影响。 和先前清醒的持续时间，以及它们之间的相互作用，对白天警觉性的测量， 在4周的睡眠限制条件下的表现。 这项研究的结果对理解慢性疾病的后果具有重要意义。 老年人睡眠不足。大多数成年人经常无法获得充足的睡眠，但很少有研究表明， 试图量化中老年人长期睡眠不足的后果。 睡眠不足会对健康、安全和生活质量产生重要影响。知识如何 健康老年人对睡眠不足的反应的警觉性、表现和记忆力将提供依据 为未来的研究和意见和建议，以保持健康和福祉，因为我们的年龄。

Insufficient sleep is a major health and safety problem for young and older adults alike. National polls indicate that more than a quarter of adults 18-84 years of age regularly sleep less than 7 h per night, with 15% reporting sleeping less than 6 h per night. The deficits in alertness and performance ability associated with insufficient sleep can lead to greater risk for automobile accidents, home and workplace accidents, and on-the-job errors in sleepy individuals. Insufficient sleep can also have a negative effect on the quality of life, with impacts on irritability, mood, and motivation. There is evidence from acute sleep deprivation studies that older adults may respond differently to sleep loss than young adults, but studies comparing the response to chronic sleep restriction in older and young adults have not yet been conducted. Here, we propose to investigate the consequences of 4 weeks of chronic insufficient sleep on daytime alertness and performance in older (55-70) and young (18-30) adults. Subjects will be scheduled to sleep an equivalent of 5 h per 24 h in a forced desynchrony protocol, in order that we can investigate both the circadian and wake-dependent contributions to alertness and performance across the 4 weeks of sleep restriction. We will use subjective and objective measures to assess alertness across each waking episode, and subjects will perform a battery of tasks several times per day to measure the consequences of sleep restriction on cognitive throughput, sustained attention, reaction time, motivation, mood and short-term memory. Our study design will allow us to assess independently the impact of time-of-day (circadian phase) and duration of prior wakefulness, as well as their interactions, on measures of daytime alertness and performance under conditions of sleep restriction across 4 weeks. Results from this study have important implications for understanding the consequences of chronic insufficient sleep in older adults. Most adults regularly fail to get sufficient sleep, but few studies have attempted to quantify the consequences of chronic insufficient sleep in middle-aged and older people. Insufficient sleep can have important effects on health, safety, and quality of life. Knowledge of how the alertness, performance, and memory of healthy older people respond to insufficient sleep will provide a basis for future research and for advice and recommendations for maintaining health and well-being as we age.