Improved Susceptometry to Measure Body Iron Stores

改进的电感受计测量体内铁储备

• 批准号: 7234392
• 负责人: HECTOR ROBERT
• 金额: $ 18.81万
• 依托单位: QUANTUM MAGNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234392
• 关键词: Affect; Appointment; Biological Models; Body measure procedure; Bone Marrow Transplantation; Brain; Clinical; Clinical Research; Collaborations; Condition; Data; Disease; Dysmyelopoietic Syndromes; Exploratory/Developmental Grant; Fatty acid glycerol esters; General Hospitals; Generations; Goals; Heart; Helium; Hemochromatosis; Hemophilia A; Hereditary hemochromatosis; Hospitals; Iron; Iron Overload; Liquid substance; Liver; Liver diseases; Lung; Magnetism; Malignant Neoplasms; Measurement; Measures; Methods; Monitor; New York; Obesity; Organ; Patients; Performance; Plant Roots; Predisposition; Presbyterian Church; Range; Rare Diseases; Sickle Cell Anemia; Signal Transduction; Skin; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Source; Spleen; Squid; System; Techniques; Technology; Temperature; Testing; Thalassemia; Tissues; Tracer; Universities; Water; Work; abdominal wall; base; cell type; cost; design; improved; innovation; instrument; leukemia; lymph nodes; next generation; nonalcoholic steatohepatitis; programs; response; sensor; treatment program

This R21 program will fundamentally improve the precision and reduce the cost of magnetic susceptometry for noninvasive measurements of body iron stores. Where existing susceptometers use expensive SQUID sensors that require liquid helium, the new susceptometer will use inexpensive magnetic sensors working at room temperature. In preliminary studies, a first-generation susceptometer with room-temperature sensors showed a good correlation (r=0.98) with an existing SQUID system. The next-generation susceptometer will resolve lower iron levels, in fatter patients, than any existing susceptometer. As a model system, this program focuses on liver iron measurements, which are the best indicator of total body iron. A new susceptometer coil geometry will minimize errors due to the susceptibility responses of the lung and abdominal wall. Errors will be reduced further by evaluating and correcting for the lung and abdominal-wall susceptibilities, as well as improving the water bag that compensates for the diamagnetic background response of the body. These improved susceptometry techniques may ultimately be used to measure iron in the brain, heart and other organs, and to detect tissue-specific magnetic tracers that highlight certain molecules and cell types, signal the presence of cancers, or indicate the function of the lymph nodes, liver and spleen.

该R21计划将从根本上提高磁电阻测量的精度并降低成本 用于非侵入性测量体内铁储存。现有的温度计使用昂贵的SQUID 需要液氦的传感器，新的磁力计将使用廉价的磁性传感器， 室温在初步研究中，第一代带有室温传感器的温度计 与现有的SQUID系统显示出良好的相关性（r=0.98）。下一代磁流变仪将 解决较低的铁水平，在肥胖患者，比任何现有的血糖仪。 作为一个模型系统，该计划侧重于肝脏铁测量，这是总铁含量的最佳指标。 身体铁。一个新的磁电阻计线圈几何形状将最大限度地减少由于磁化率响应的误差， 肺和腹壁。通过评估和校正肺部和 腹壁磁化率，以及改善补偿抗磁性的水囊 身体的背景反应。 这些改进的铁含量测定技术最终可能被用于测量大脑、心脏和大脑中的铁含量。 其他器官，并检测组织特异性磁示踪剂，突出某些分子和细胞类型， 提示癌症的存在，或指示淋巴结、肝脏和脾脏的功能。