Bruker 800 MHz TCI CryoProbe

布鲁克 800 MHz TCI CryoProbe

• 批准号: 7046272
• 负责人: Robert Thompson Clubb
• 金额: $ 30.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7046272
• 关键词: nucleic acids; proteins

DESCRIPTION (provided by applicant): Funding is requested for an 800 MHz NMR CryoProbe to support the research of a group of NIH, NSF and DOE funded scientists at UCLA, this probe will be used to help solve the structures and dynamics of proteins, nucleic acids, DNA-protein, RNA-protein, and protein-protein complexes proposed for investigation by the major users. The research projects of the six major users are described with the following titles: (1) NMR studies of proteins and their complexes (Clubb), (2) Structural studies of nucleic acids and complexes (Feigon), (3) SAM domain structure and function (Bowie), (4) Structure/function of HIV-1 Vpr and HHR23A associated cellular proteins (Chen), (5) Regulation of phage lambda site-specific DMA recombination by Xis and Fis (Johnson), and (6) Chaos Control and Sensitivity Enhancement in Biomolecular NMR (Lin). The probe will be located in the UCLA-DOE NMR Technology Center. It will significantly improve the sensitivity of the Center's single 800 MHz spectrometer enabling a greater number of projects to benefit from access to this high-field instrument.

描述（由申请人提供）：要求提供800 MHz NMR CryoProbe的资金，以支持UCLA的NIH，NSF和DOE资助科学家的研究，该探针将用于帮助解决主要用户提出的蛋白质，核酸，DNA-蛋白质，RNA-蛋白质和蛋白质-蛋白质复合物的结构和动力学研究。六个主要用户的研究项目用以下标题描述：（1）蛋白质及其复合物的NMR研究（Clubb），（2）核酸和复合物的结构研究（Feigon），（3）SAM结构域结构和功能（Bowie），（4）HIV-1 Vpr和HHR 23 A相关细胞蛋白的结构/功能（Chen），（5）Xis和Fis对噬菌体λ位点特异性DNA重组的调节（约翰逊），和（6）生物分子NMR中的混沌控制和灵敏度增强（Lin）。探头将位于UCLA-DOE NMR技术中心。它将大大提高该中心的单一800兆赫频谱仪的灵敏度，使更多的项目能够受益于这一高场仪器。