Bruker Avance III Console and QCI Cryoprobe for a 600 MHz NMR Spectrometer

描述(由申请人提供)：一组NIH支持的调查人员申请资金购买Avance III 600 HD核磁共振控制台和QCI核磁共振CryoProbe。该设备将用于显著升级加州大学洛杉矶分校核磁共振核心设施中现有的共享600 MHz核磁共振光谱仪。我们想要升级的旧仪器被加州大学洛杉矶分校的一些研究小组大量使用，但由于它的老化，已经变得过时和不可靠。具体地说，我们申请资金购买Avance III HD控制台，用于更换1996年安装的过时的DRX控制台。还需要资金购买QCI CryoProbe，它将取代2003年安装的较旧型号的TXI低温探头。安装新的控制台和CryoProbe将极大地提高600 MHz光谱仪的效用。这是因为翻新后的仪器将具有更高的灵敏度(高达2倍)，并能够执行碳检测实验和提高核磁共振数据采集效率的非线性采样方法。新的仪器预计也将比现有的核磁共振光谱仪可靠得多，现有的核磁共振光谱仪容易出现故障，维护成本也越来越高。新设备将由一名经验丰富的博士级别的工作人员科学家管理，他在过去15年中成功地维护和操作了该设施的核磁共振仪器。此外，如果获得这笔赠款，加州大学洛杉矶分校承诺提供资金，在需要时翻新14.1Tesla超导磁体。这意味着600 MHz光谱仪的所有组件最终都将升级，这将确保它在未来十年或更长时间内继续成为加州大学洛杉矶分校科学家的宝贵资源。

DESCRIPTION (provided by applicant): A group of NIH supported investigators requests funds to purchase an Avance III 600 HD NMR console and a QCI NMR CryoProbe. This equipment will be used to significantly upgrade an existing shared 600 MHz NMR spectrometer that is housed in the UCLA-DOE NMR Core Facility. The older instrument we would like to upgrade is heavily used by a number of research groups at UCLA, but has become obsolete and unreliable because of its advancing age. Specifically, we request funds to purchase an Avance III HD console that will be used to replace an outdated DRX console that was installed in 1996. Funds are also requested to purchase a QCI CryoProbe, which will replace an older model TXI cryoprobe installed in 2003. Installation of a new console and CryoProbe will dramatically increase the utility of the 600 MHz spectrometer. This is because the refurbished instrument will have improved sensitivity (up to 2-fold), and the ability to perform carbon-detected experiments and non-linear sampling methods that improve the efficiency of NMR data acquisition. The new instrumentation is also expected to be significantly more reliable than the existing NMR spectrometer, which is prone to breakdown and increasingly costly to maintain. The new equipment will be managed by an experienced Ph.D.-level staff scientist, who has successfully maintained and operated NMR instrumentation at the facility for the past 15 years. Also, if awarded this grant, UCLA has committed funds to refurbish the 14.1 Tesla superconducting magnet when it is needed. This means that all the components of the 600 MHz spectrometer will ultimately be upgraded, which will ensure that it will continue to be a valuable resource to UCLA scientists for a decade or more.