Bruker Avance III Console and QCI Cryoprobe for a 600 MHz NMR Spectrometer

描述（由申请人提供）：一组NIH支持的研究人员申请资金购买Avance III 600 HD核磁共振控制台和QCI核磁共振冷冻探针。该设备将用于显著升级现有的共享600 MHz核磁共振光谱仪，该光谱仪位于加州大学洛杉矶分校-美国能源部核磁共振核心设施中。我们想要升级的旧仪器被加州大学洛杉矶分校的许多研究小组大量使用，但由于其年龄的增长，它已经过时且不可靠。具体来说，我们要求资金购买Avance III HD主机，用于替换1996年安装的过时DRX主机。还要求资金购买QCI冷冻探针，它将取代2003年安装的老式TXI冷冻探针。安装一个新的控制台和CryoProbe将大大增加600 MHz光谱仪的效用。这是因为翻新后的仪器将具有更高的灵敏度（高达2倍），并且能够进行碳检测实验和非线性采样方法，从而提高核磁共振数据采集的效率。新的仪器也有望比现有的核磁共振光谱仪更可靠，后者容易发生故障，维护成本也越来越高。新设备将由一位经验丰富的博士级科学家管理，他在过去的15年里成功地维护和操作了该设施的核磁共振仪器。此外，如果获得这笔拨款，加州大学洛杉矶分校将承诺在需要时翻新14.1特斯拉超导磁体。这意味着600兆赫光谱仪的所有组件最终都将升级，这将确保它在十年或更长时间内继续成为加州大学洛杉矶分校科学家的宝贵资源。

DESCRIPTION (provided by applicant): A group of NIH supported investigators requests funds to purchase an Avance III 600 HD NMR console and a QCI NMR CryoProbe. This equipment will be used to significantly upgrade an existing shared 600 MHz NMR spectrometer that is housed in the UCLA-DOE NMR Core Facility. The older instrument we would like to upgrade is heavily used by a number of research groups at UCLA, but has become obsolete and unreliable because of its advancing age. Specifically, we request funds to purchase an Avance III HD console that will be used to replace an outdated DRX console that was installed in 1996. Funds are also requested to purchase a QCI CryoProbe, which will replace an older model TXI cryoprobe installed in 2003. Installation of a new console and CryoProbe will dramatically increase the utility of the 600 MHz spectrometer. This is because the refurbished instrument will have improved sensitivity (up to 2-fold), and the ability to perform carbon-detected experiments and non-linear sampling methods that improve the efficiency of NMR data acquisition. The new instrumentation is also expected to be significantly more reliable than the existing NMR spectrometer, which is prone to breakdown and increasingly costly to maintain. The new equipment will be managed by an experienced Ph.D.-level staff scientist, who has successfully maintained and operated NMR instrumentation at the facility for the past 15 years. Also, if awarded this grant, UCLA has committed funds to refurbish the 14.1 Tesla superconducting magnet when it is needed. This means that all the components of the 600 MHz spectrometer will ultimately be upgraded, which will ensure that it will continue to be a valuable resource to UCLA scientists for a decade or more.