PROG 9- Cancer Epidemiology

PROG 9-癌症流行病学

• 批准号: 7438444
• 负责人: Alice Whittemore
• 金额: $ 1.7万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-04 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7438444
• 关键词: Acculturation; Affect; Archives; Area; BRCA1 Mutation; Behavioral Genetics; Breast; California; Cancer Burden; Cancer Care Outcomes Research and Surveillance Consortium; Cancer Center; Cancer Patient; Cancer Research Project; Case-Control Studies; Cessation of life; Characteristics; Cohort Studies; Complex; Contraceptive Usage; DNA; Data; Data Collection; Data Quality; Development; Diffusion; Direct Costs; Elevation; Environment; Epidemiologic Studies; Epidemiologist; Ethnic Origin; Etiology; Family; Family-Based Registry; Funding; Future; Goals; Helicobacter Infections; Immigration; Incidence; Individual; Knowledge; Lead; Lymphocyte; Malignant Neoplasms; Malignant neoplasm of esophagus; Malignant neoplasm of ovary; Medical; Medical Surveillance; Molecular Genetics; Morbidity - disease rate; Numbers; Operative Surgical Procedures; Oral; Outcome; Ovary; Patients; Pattern; Patterns of Care; Peripheral; Population; Population Heterogeneity; Prostate Lymphoma; Provider; Publications; Quality of life; Race; Recording of previous events; Recurrence; Research; Research Personnel; Resource Sharing; Resources; Risk; Sampling; San Francisco; Scheme; Socioeconomic Status; System; Translational Research; Universities; Work; base; cancer care; cancer epidemiology; cancer prevention; cancer risk; cancer site; cancer therapy; case control; ethnic difference; follow-up; improved; innovation; interdisciplinary approach; interdisciplinary collaboration; interest; malignant breast neoplasm; member; mortality; multidisciplinary; new technology; prevent; programs; racial and ethnic; teacher; tumor; tumor progression

The goal of the Cancer Epidemiology Program (CEP) is to improve our ability to prevent cancer and reduce its burden through new knowledge in surveillance, etiology, patterns of care, and survival, using an interdisciplinary approach. Special emphasis is placed on racial, ethnic, cultural, and other groups with an unequal burden of cancer. This research has been conducted primarily via large populationbased case-control and cohort studies in the ethnically diverse population of the San Francisco Bay Area, which includes Oakland and San Jose. Case-control studies typically collect demographic and exposure data, DNA from peripheral lymphocytes, and/or archived tumor samples. Cohort studies are based on follow-up of healthy individuals for cancer incidence (e.g., California Teachers Study), and of incident cases for cancer care, quality of life, and survival (e.g., CanCORS and Family Registries). Cancer sites of particular interest include breast, ovary, prostate, and lymphomas. This work has been facilitated and enhanced by the recent formal affiliation between Stanford University and the Northern California Cancer Center (NCCC). Some highlights of Program research include findings that oral contraceptive use is associated with reduced ovarian cancer risk and no elevation in breast cancer risk among carriers of BRCA1 mutations, that Helicobacter pylori infection is associated with reduced risk of esophageal cancer, that ethnic differences exist in use of alternative cancer therapies, and that choice of breastconserving surgery is related to socioeconomic status, immigration status and acculturation, and race/ethnicity. The Program adds value to the Cancer Center through its population-based study resources that provide a strong basis for developing important interdisciplinary collaborations and conducting translational research. Dr. Alice S. Whittemore and Dr. Esther M. John lead the Program, both senior cancer epidemiologists with extensive cancer research programs who have worked together for over 15 years. The CEP consists of 23 members, with direct cost funding of $20,220,819, including $6,463,763 in NCI funding. In the period from 2000 to the present, the average number of publications by Program members was 33 per year; of these, 40% were intra-programmatic and 14% were interprogrammatic. Future plans include expanding intra- and inter-programmatic interactions among investigators, identifying new research opportunities, and evaluating the feasibility of a data collection Shared Resource within the Cancer Center.

癌症流行病学计划（CEP）的目标是提高我们预防癌症的能力， 通过监测、病因学、护理模式和生存方面的新知识，使用 跨学科的方法。特别强调的是种族、民族、文化和其他群体 癌症的负担不平等。这项研究主要是通过基于大量人口的 在旧金山弗朗西斯科湾地区不同种族人群中进行的病例对照和队列研究， 包括奥克兰和圣何塞。病例对照研究通常收集人口统计学和暴露 数据、来自外周淋巴细胞的DNA和/或存档的肿瘤样品。队列研究基于 跟踪健康个体的癌症发病率（例如，加州教师研究），以及 癌症护理、生活质量和生存的案例（例如，CanCORS和家庭登记处）。癌症部位 特别感兴趣的包括乳腺、卵巢、前列腺和淋巴瘤。这项工作得到了促进， 最近斯坦福大学和北方加州之间的正式联系加强了这一点 癌症中心（NCCC）。方案研究的一些重点包括口服避孕药 在携带者中，使用该药与降低卵巢癌风险相关，但不增加乳腺癌风险 BRCA 1突变，幽门螺杆菌感染与食管癌风险降低相关 癌症，在使用替代癌症疗法方面存在种族差异， 手术与社会经济地位、移民地位和文化适应有关， 种族/民族。该计划通过其基于人群的研究为癌症中心增加了价值 为发展重要的跨学科合作提供坚实基础的资源， 进行翻译研究。Alice S.作者声明：Dr.约翰领导了这个项目， 他们都是拥有广泛癌症研究项目的资深癌症流行病学家， 已经超过15年了CEP由23个成员组成，直接费用资金为20，220，819美元，包括 NCI资助6，463，763美元。从2000年至今， 每年有33个项目，其中40%是项目内项目，14%是项目间项目。 今后的计划包括扩大方案内和方案间的互动， 研究人员，确定新的研究机会，并评估数据收集的可行性 癌症中心内的共享资源。