PROG 7- Cancer Immunology and Immunotherapy

PROG 7-癌症免疫学和免疫治疗

• 批准号: 7438440
• 负责人: EDGAR G. ENGLEMAN
• 金额: $ 1.7万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-04 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7438440
• 关键词: Biochemical; Cancer Center; Cancer Immunology Science; Cells; Development; Educational process of instructing; Effector Cell; Faculty; Goals; Grant; Immune; Immune response; Immune system; Immunobiology; Immunologic Monitoring; Immunotherapy; Measures; Medical Students; Medicine; Molecular; Nature; Operative Surgical Procedures; Participant; Pathology; Patients; Pattern; Postdoctoral Fellow; Research; Research Personnel; Resource Sharing; Signal Pathway; Solid Neoplasm; Specificity; System; T-Lymphocyte; Toxic effect; Training; Tumor Immunity; Universities; cancer immunology function; interest; medical schools; member; programs; response; trafficking; tumor; tumor eradication

The Program in Cancer Immunology and Immunotherapy is focused on understanding the interactions between the host immune system and tumors, and on the discovery and development of clinically effective anti-tumor immunotherapy. The Program is comprised of highly interactive faculty members whose academic interests are in molecular and cellular immunobiology, medicine, surgery and pathology in the Stanford University School of Medicine. Each faculty member has his or her own research program that is supported by investigator initiated grants. In addition, each faculty member is active in teaching graduate and medical students, as well as training postdoctoral fellows and residents. Three complementary approaches are being taken to achieve the three goals of our program. ¿ To manipulate cells of the immune system in patients with tumors with the goal of utilizing the exquisite specificity of this system to achieve tumor eradication without significant toxicity. ¿ To develop new and more precise ways of measuring and monitoring the immune response to tumors in tumor-bearing hosts. ¿ To develop an understanding of the biochemical and signaling pathways used by T cells and other immune effector cells in both their response to tumors and their cellular trafficking patterns. Understanding and manipulating the immune response to tumors, particularly solid tumors, is the major unifying research interest of the participants in this Research Program, and our ability to achieve our objectives is highly dependent on both basic and translational investigators from the other Programs in the Cancer Center and on the Shared Resources.

癌症免疫学和免疫治疗项目的重点是了解相互作用 宿主免疫系统和肿瘤之间的关系，以及临床上 有效的抗肿瘤免疫疗法。该计划由高度互动的教师组成 他的学术兴趣是分子和细胞免疫生物学，医学，外科和 病理学在斯坦福大学医学院。每个教师都有自己的 由研究人员发起的赠款支持的研究计划。此外，每一位教师都是 积极从事研究生和医学生的教学，以及博士后研究员和住院医师的培训。 目前正在采取三种互补的方法来实现我们方案的三个目标。 操作肿瘤患者的免疫系统细胞，目的是利用 该系统具有精确的特异性，以实现肿瘤根除而无显著毒性。 开发新的和更精确的方法来测量和监测免疫反应， 肿瘤宿主体内的肿瘤。 ·了解T细胞和其他细胞所使用的生物化学和信号传导途径 免疫效应细胞在它们对肿瘤的应答和它们的细胞运输模式中的作用。 理解和操纵对肿瘤的免疫反应，特别是实体瘤，是主要的 统一研究兴趣的参与者在这个研究计划，我们的能力，以实现我们的 目标高度依赖于其他项目的基础和翻译研究人员， 癌症中心和共享资源。