Locomotion Control by Lumbar Spinal Cord Stimulation

通过腰部脊髓刺激进行运动控制

• 批准号: 7340721
• 负责人: Changfeng Tai
• 金额: $ 25.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-10 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7340721
• 关键词: Acute; Air; Animal Model; Bilateral; Brain; Chronic; Complex; Depth; Dorsal; Electric Stimulation; Electrodes; Equilibrium; Exhibits; Fatigue; Felis catus; Goals; Hindlimb; Human; Implant; Intramuscular; Invasive; Joints; Lifting; Location; Locomotion; Lower Extremity; Lumbar spinal cord structure; Microelectrodes; Movement; Muscle; Muscle Fatigue; Neurostimulation procedures of spinal cord tissue; Numbers; Paralysed; Patients; Peripheral; Physiological; Research Personnel; Resistance; Side; Spinal; Spinal Canal; Spinal Cord; Spinal cord injury; Spinal cord injury patients; Surface; Testing; Time; Training; Walking; Weight-Bearing state; awake; base; design; desire; experience; foot; human study; improved; neuroprosthesis; programs; relating to nervous system; success

After spinal cord injury (SCI) above the lumbar level, the lower limbs will be paralyzed due to the loss of descending commands from the brain. However, after SCI the interneuronal network in lumbar spinal cord can still sustain locomotor function such as air-stepping. Chronic SCI cats can also stand or walk for a short time on a treadmill after training. Patients with incomplete SCI can regain over ground mobility after extensive treadmill training. All of these observations indicate that the interneuronal network in lumbar spinal cord can carry out locomotion after SCI, if it can be activated properly. Therefore, we propose in this project to electrically activate the lumbar interneuronal locomotor network in cats to restore walking function after SCI. Previous studies have shown that the lumbar interneuronal locomotor network can be activated with only a few electrodes to elicit complex, coordinated, multi-joint movements. Such movements require many electrodes when traditional peripheral neuromuscular stimulation is used: Other advantages of spinal cord stimulation include: (1). electrodes in spinal canal experience relatively small movements, and thus exhibit less breakage, than the intramuscular electrodes; (2). the lumbar interneuronal locomotor network can activate muscles in a physiological recruitment order, which is more resistant to fatigue. Muscle fatigue is a major problem in the peripheral neuromuscular stimulation. In this project we will identify the effective stimulation locations and develop the control strategy to restore walking function in SCI cats, using extra- spinal electrical stimulation of the lumbar spinal cord in combination with intra-spinal stimulation. The extra- spinal electrode is less invasive to the spinal cord than the intra-spinal electrode, but the intra-spinal electrode is more effective than the extra-spinal electrode to activate the neural component deep in the lumbar spinal cord. The success of this study in cat will suggest how human studies could be pursued. The long-term goal of this project is to develop a new neuroprosthesis for locomotion based on lumbar spinal cord stimulation. The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients.

腰椎以上的脊髓损伤（SCI）后，由于失去了 从大脑中下达命令然而，脊髓损伤后，腰髓神经元间网络 仍然可以维持运动功能，比如空中踏步慢性SCI猫也可以站立或行走一段时间。 训练后在跑步机上跑步。不完全性SCI患者可以在术后恢复地面活动能力。 广泛的跑步机训练。所有这些观察结果表明，腰椎间盘神经元网络， 脊髓损伤后，如果能够适当激活，脊髓可以进行运动。因此，我们在本项目中建议， 电激活猫的腰部神经元间运动网络，以恢复猫在 sci.先前的研究表明，腰椎神经元间运动网络可以被激活， 只需要几个电极就能引起复杂的、协调的、多关节的运动。这种运动需要许多 使用传统外周神经肌肉刺激时的电极：脊髓的其他优点 刺激包括：（1）.椎管中的电极经历相对小的运动， 断裂比肌内电极少;（2）.腰椎神经元间运动网络可以 激活肌肉在生理招聘秩序，这是更耐疲劳。肌肉疲劳是一种 周围神经肌肉刺激的主要问题。在这个项目中，我们将确定有效的 刺激位置，并制定控制策略，以恢复SCI猫的行走功能，使用额外的- 腰脊髓的脊髓电刺激结合脊髓内刺激。临时演员- 脊髓电极比脊髓内电极对脊髓的侵入性更小，但是脊髓内电极 电极比脊髓外电极更有效地激活脊髓深处的神经成分。 腰脊髓这项研究在猫身上的成功将提示如何进行人类研究。的 该项目的长期目标是开发一种新的基于腰椎的运动神经假体 脊髓刺激拟议的研究不仅将提高我们对运动控制的理解， 腰髓也有益于脊髓损伤患者。

项目成果

Hindlimb movement in the cat induced by amplitude-modulated stimulation using extra-spinal electrodes.

使用脊髓外电极进行调幅刺激引起猫的后肢运动。

• DOI: 10.1088/1741-2560/5/2/002
• 发表时间: 2008
• 期刊: Journal of neural engineering
• 影响因子: 4
• 作者: Tai,Changfeng;Wang,Jicheng;Shen,Bing;Wang,Xianchun;Roppolo,JamesR;deGroat,WilliamC
• 通讯作者: deGroat,WilliamC