FUNCTION OF THE GAMMAHV68 M2 ANTIGEN

GAMMAHV68 M2 抗原的功能

• 批准号: 7349211
• 负责人: SAMUEL H SPECK
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349211
• 关键词: antigens; infection; lead; lymphoma; model; neoplasm /cancer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gammaherpesviruses are closely associated with the development of lymphoproliferative disease and lymphomas, as well as other cancers. The long-term goal of this research is to understand how gammaherpesviruses manipulate normal B or T cell development to persist within the lymphoid compartment of the infected host. Understanding the mechanisms used by gammaherpesviruses to persist in the infected host may lead to the development of strategies for interfering with chronic infection. The focus of the proposed studies on murine gammaherpesvirus 68 (gHV68; also referred to as MHV-68) represents an ongoing effort to develop a tractable small animal model for characterizing establishment and maintenance of gammaherpesvirus infection. The proposed studies focus on determining the function of one of the critical latency-associated antigens of gHV68, the M2 antigen).

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。伽马疱疹病毒与淋巴增生性疾病和淋巴瘤以及其他癌症的发展密切相关。这项研究的长期目标是了解伽马疱疹病毒如何操纵正常的B或T细胞发育，使其持续存在于受感染宿主的淋巴间隔内。了解伽玛疱疹病毒在受感染宿主中持续存在的机制可能会导致制定干预慢性感染的策略。关于小鼠伽马疱疹病毒68(gHV68；又称MHV-68)的拟议研究的重点是开发一种可驯化的小动物模型，以表征伽马疱疹病毒感染的建立和维持。拟议的研究重点是确定gHV68的关键潜伏期相关抗原之一M2抗原的功能。