WHOLE ANIMAL IMAGING TO COMPARE TRANSGENE EXPRESSION IN RODENTS AND PRIMATES

通过整体动物成像来比较啮齿类动物和灵长类动物中的转基因表达

• 批准号: 7349702
• 负责人: GARY H RHODES
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349702
• 关键词: WHOLE; ANIMAL; IMAGING; COMPARE; TRANSGENE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: In the last decade, a variety of techniques have been developed which allow noninvasive imaging of reporter genes expressed within a live animal. NMR, PET and optical imaging techniques have all been developed and each has its advantages and disadvantages. The optical techniques were made possible by the development of sensitive and inexpensive CCD cameras and also by the realization that light emitted in the interior of the body is transported to the exterior with suprisingly little attentuation.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：在过去的十年中，已经开发了各种技术，允许在活动物内表达的报告基因的非侵入性成像。核磁共振、正电子发射断层扫描和光学成像技术都已发展起来，各有其优点和缺点。光学技术之所以成为可能，是因为灵敏而廉价的CCD摄像机的发展，以及身体内部发出的光以惊人的小衰减传输到外部的实现。