Request for Whole Animal Tomographic Fluorescence Imaging Equipment

请求全动物断层荧光成像设备

• 批准号: 8051149
• 负责人: Stephen H Thorne
• 金额: $ 34.9万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8051149
• 关键词: Animals; Bioluminescence; Biomedical Research; Communities; Core Facility; Disease; Equipment; Fluorescence; Funding; Housing; Image; Imaging Device; Individual; Institution; Medical Research; Medicine; Methods; Neck; Optics; Research; Research Project Grants; Schools; Services; System; Time; Universities; base; fluorescence imaging; in vivo; instrument; molecular imaging; operation; pre-clinical; research clinical testing; tool

DESCRIPTION (provided by applicant): Request for whole animal tomographic fluorescence imaging equipment Optical (bioluminescence and fluorescence) non-invasive molecular imaging of small animals has become a key research tool in the understanding of a variety of diseases, and in the pre-clinical evaluation of therapies to treat them. These approaches are rapidly becoming a primary tool for use in biomedical research. This application seeks funds to place an automated and tomographic far-red and near-infrared fluorescence-imaging instrument within the Small Animal Imaging Core (SAIC) at the University of Pittsburgh. This instrument will be both a critical addition to the available repertoire of imaging apparatus within the center but will also be the only dedicated core whole animal fluorescence imaging system available on campus. This request is for funds to purchase a non-invasive, fluorescence imaging VisEn FMT2500 system. This instrument will be housed within the Small Animal Imaging Core at the University Of Pittsburgh School Of Medicine. The mandate of this core facility is to provide access to a full range of in vivo molecular imaging devices, analysis, and morphometric methods to all research groups within the University Of Pittsburgh School Of Medicine. Optical in vivo imaging is an essential service provided by the center. The reasons for this application are to: 1: Provide access to dedicated non-invasive and tomographic fluorescence imaging within the Center and 2: to provide additional instrument time. Since the SAIC commenced operations, it has become an integral part of the medical research community currently participating in research projects. The available bioluminescence imaging system has only limited fluorescence imaging capability and does not have tomographic capabilities. Furthermore as the PHS funded user base within the institution continues to expand, a lack of available imaging time has become a limiting factor in the utility of the center. The acquisition of a dedicated, tomographic fluorescence in vivo imaging instrument will allow individual users more ready access to additional optical molecular imaging capabilities and will help alleviate the current user bottle neck for imaging time.

描述（由申请人提供）： 对小动物的光学（生物发光和荧光）非侵入性分子成像已成为了解各种疾病和治疗方法的临床前评估的关键研究工具。这些方法正在迅速成为生物医学研究中使用的主要工具。该申请旨在获得资金，以便在匹兹堡大学的小动物成像核心（SAIC）内放置自动化和断层扫描远红外和近红外荧光成像仪器。该仪器将是该中心现有成像设备的重要补充，也将是校园内唯一的专用核心整体动物荧光成像系统。该申请是为了购买非侵入性荧光成像VisEn FMT 2500系统的资金。该仪器将存放在匹兹堡大学医学院的小动物成像中心内。该核心设施的任务是为匹兹堡大学医学院的所有研究小组提供全方位的体内分子成像设备、分析和形态测量方法。光学活体成像是该中心提供的一项重要服务。该申请的原因是：1：在中心内提供专用的非侵入性和断层扫描荧光成像; 2：提供额外的仪器时间。自SAIC开始运作以来，它已成为目前参与研究项目的医学研究界的一个组成部分。可用的生物发光成像系统仅具有有限的荧光成像能力，并且不具有断层摄影能力。此外，随着机构内PHS资助的用户群继续扩大，缺乏可用的成像时间已成为该中心实用性的限制因素。一个专用的，断层荧光在体内成像仪器的收购将允许个人用户更容易获得额外的光学分子成像能力，并将有助于缓解目前的用户瓶颈成像时间。