Drug/Cue Interactions in Alcohol-Tobacco Comorbidity

酒精-烟草合并症中的药物/提示相互作用

• 批准号: 7031072
• 负责人: DAVID J DROBES
• 金额: $ 31.98万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7031072
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; comorbidity; craving; cues; drug interactions; health behavior; human middle age (35-64); human subject; neurotoxicology; nicotine; psychophysiology; smoking; substance abuse epidemiology; tobacco abuse; young adult human (21-34)

DESCRIPTION (provided by applicant): Extensive research has documented strong associations between alcohol and tobacco use. Various mechanisms have been invoked to explain a dual addiction to alcohol and nicotine, as well as the strong association between alcohol and tobacco intake across a range of consumption levels. Among them, behavioral models assert that associative learning occurs as a consequence of the frequent contemporaneous use of these two drugs. Using these models as a conceptual framework, preliminary work in our laboratory has demonstrated that alcohol cues and smoking cues elicit both strong cravings to drink alcohol and cravings to smoke (i.e., "cross-cue reactivity") in alcoholic smokers. Similar patterns, albeit to a lesser extent, were observed in alcoholic nonsmokers and non-alcoholic smokers. The work proposed in this competitive continuation application extends this line of research by examining the separate and combined influence of alcohol/nicotine intake and salient substance cues on a broad range of subjective, physiological, and behavioral reactions. Using primarily within-subjects design features and established placebo control drug administration methods, Study 1 will investigate cravings and physiological reactivity to pictorial alcohol, smoking, and neutral cues in the presence of alcohol and/or nicotine. Study 2 will further examine the influence of alcohol and nicotine drug/cue manipulations on alcohol self administration. Both studies will examine subjects across a broad range of alcohol and tobacco use patterns, and statistical models will evaluate the extent to which pharmacological and cue based effects are influenced by individual differences in alcohol and tobacco intake. Overall, the proposed research will provide valuable basic data regarding the separate and combined influences of alcohol, nicotine, and relevant cues on multidimensional aspects of alcohol and smoking cue reactivity.

描述（由申请人提供）：广泛的研究已经证明了酒精和烟草使用之间的强烈关联。人们援引了各种机制来解释酒精和尼古丁的双重成瘾，以及在各种消费水平上酒精和烟草摄入量之间的强烈关联。其中，行为模型断言，联想学习的发生是频繁同时使用这两种药物的结果。使用这些模型作为概念框架，我们实验室的初步工作已经证明，酒精暗示和吸烟暗示会引起强烈的饮酒欲望和吸烟欲望（即，“交叉线索反应”）。类似的模式，尽管程度较低，在酒精非吸烟者和非酒精吸烟者中也观察到了。这项竞争性继续申请中提出的工作通过检查酒精/尼古丁摄入量和显着物质线索对广泛的主观，生理和行为反应的单独和综合影响来扩展这一研究领域。主要使用受试者内设计特征和已建立的安慰剂对照药物给药方法，研究1将研究在存在酒精和/或尼古丁的情况下对图像酒精、吸烟和中性线索的渴望和生理反应。研究2将进一步检查酒精和尼古丁药物/线索操作对酒精自我给药的影响。这两项研究都将检查广泛的酒精和烟草使用模式的受试者，统计模型将评估酒精和烟草摄入量个体差异对药理学和基于线索的效应的影响程度。总体而言，拟议的研究将提供有关酒精，尼古丁和相关线索对酒精和吸烟线索反应性的多维方面的单独和综合影响的有价值的基础数据。