Influence of Smoking Abstinence and Age on ERP Indices of Attentional Control

戒烟情况和年龄对注意力控制ERP指数的影响

• 批准号: 7666622
• 负责人: DAVID J DROBES
• 金额: $ 24.4万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7666622
• 关键词: Abstinence; Address; Adult; Age; Age-associated memory impairment; Aged, 80 and over; Aging; Aging-Related Process; Alzheimer' s Disease; Animals; Area; Attention; Attention Deficit Disorder; Automobile Driving; Back; Behavioral; Brain; Cigarette; Cigarette Smoker; Cognition; Cognitive; Cognitive deficits; Data Analyses; Dependence; Development; Double-Blind Method; Event; Event-Related Potentials; Exhibits; Experimental Designs; Goals; Human; Impaired cognition; Individual; Intelligence; Laboratories; Lead; Light; Longevity; Measures; Modeling; Monitor; Motivation; Nicotine; Nicotine Withdrawal; Older Population; Participant; Performance; Pharmacological Treatment; Population; Process; Psychological reinforcement; Relative (related person); Research; Research Methodology; Role; Satiation; Scalp structure; Schizophrenia; Self Medication; Short-Term Memory; Smoke; Smoker; Smoking; Smoking Behavior; Source; Subgroup; Withdrawal; addiction; age group; cognitive function; deprivation; executive function; experience; improved; indexing; insight; interest; normal aging; public health relevance; response; smoking cessation

DESCRIPTION (provided by applicant): Nicotine withdrawal is associated with diminished attentional cognitive processing, and nicotine administration is associated with increased attentional cognitive processing. Given that the normal aging process is associated with declines in attentional control, we propose that nicotine derived from smoking among older populations acutely ameliorates the decline in attentional control associated with aging. Thus, older individuals might find smoking more reinforcing for cognitive-attentional reasons. The role of nicotine-induced cognitive-attentional enhancement as a function of age has not yet been systematically investigated. The primary aim of the proposed research is to examine effects of nicotine satiation versus withdrawal on cognitive-attentional performance among heavy smokers as a function of the normal aging process. Younger (21 to 40 years old) and older (51 to 70 years old) smokers will be compared on an executive attention working memory task (N-back) during two laboratory sessions, following either ad lib smoking or overnight nicotine deprivation. Data analyses will focus on event- related brain potential (ERP) activity during the working memory task, as well as behavioral responses. We hypothesize that attentional control will be diminished during nicotine withdrawal, this effect will be greater among older smokers, and that this effect will be greater with increasing task difficulty. PUBLIC HEALTH RELEVANCE: The proposed study will improve our understanding of the role of attentional cognitive processing in smoking behavior across the lifespan. Findings from this research may lead to the development of targeted behavioral and pharmacological treatments for older smokers.

描述（由申请人提供）：尼古丁戒断与注意力认知处理减弱相关，尼古丁施用与注意力认知处理增强相关。鉴于正常的衰老过程与注意力控制力的下降有关，我们认为老年人群中吸烟产生的尼古丁可以显着改善与衰老相关的注意力控制力的下降。因此，老年人可能会发现吸烟更能增强认知注意力。尼古丁诱导的认知注意力增强作为年龄函数的作用尚未得到系统研究。拟议研究的主要目的是检查尼古丁饱足感与戒断对重度吸烟者认知注意力表现的影响，作为正常衰老过程的函数。年轻（21 至 40 岁）和年长（51 至 70 岁）吸烟者将在随意吸烟或隔夜尼古丁剥夺后的两次实验室测试中对执行注意力工作记忆任务（N-back）进行比较。数据分析将重点关注工作记忆任务期间事件相关的大脑电位（ERP）活动以及行为反应。我们假设，在尼古丁戒断过程中，注意力控制会减弱，这种影响在老年吸烟者中会更大，并且随着任务难度的增加，这种影响会更大。公共健康相关性：拟议的研究将提高我们对注意力认知处理在整个生命周期吸烟行为中的作用的理解。这项研究的结果可能会导致针对老年吸烟者开发有针对性的行为和药物治疗方法。