Exploiting bacterial metal resistance machinery for metal ion nano-biosensors development

利用细菌金属电阻机制进行金属离子纳米生物传感器的开发

• 批准号: FT140101285
• 负责人: Prof Vipul Bansal
• 金额: $ 61.1万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-07-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140101285
• 关键词: Exploiting; bacterial; metal; resistance; machinery

This project aims to integrate advanced materials chemistry, molecular biology, bio-electrochemical and synchrotron imaging approaches to understand the role of silver resistance machinery of bacteria in their ability to form silver nanoparticles. This aims to enable discovery of new metal-specific reductase enzymes. The fundamental biomolecular understanding of bacterial silver resistance will allow the use of a silver-binding protein to develop a series of next-generation nano-biosensors. These biosensing platforms will provide high-throughput, cost-effective, selective, sensitive and continuous monitoring of heavy metal ions in effluents from mining and mineral processing industries in a real-time fashion.

本项目旨在整合先进的材料化学、分子生物学、生物电化学和同步辐射成像方法，以了解细菌的银抗性机制在其形成银纳米颗粒的能力中的作用。这旨在发现新的金属特异性还原酶。对细菌银抗性的基本生物分子理解将允许使用银结合蛋白来开发一系列下一代纳米生物传感器。这些生物传感平台将以实时方式对采矿和矿物加工工业废水中的重金属离子进行高通量、高成本效益、有选择性、灵敏和连续的监测。