Alcohol Center Of Research -- Nebraska (ACORN)

内布拉斯加州酒精研究中心 (ACORN)

• 批准号: 10526252
• 负责人: Carol A. Casey
• 金额: $ 156.95万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-28 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10526252
• 关键词: Address; Age; Aging; Alcohol consumption; Alcoholic Fatty Liver; Alcoholic Liver Diseases; Alcohols; Aldehydes; Animals; Area; Bacterial Pneumonia; Basic Science; Biology; Brain; Categories; Cell model; Cigarette; Collaborations; Dedications; Development; Disease; Disease Progression; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Event; Exposure to; Faculty; Foundations; Functional disorder; Funding; Funding Opportunities; Future; Goals; Grant; Health; Heart Injuries; Hepatic; Hepatitis B Infection; Human; Immune; Immunity; Incidence; Individual; Infection; Institution; Interdisciplinary Study; Investigation; Knowledge; Liver; Lung; Marijuana Smoking; Medical center; Molecular; National Institute on Alcohol Abuse and Alcoholism; Natural Immunity; Nature; Nebraska; Nutritional; Nutritional status; Obesity; Occupational; Organ; Physiology; Pilot Projects; Predisposition; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Services; Shapes; Signal Transduction; Structure; Talents; Tissue Model; Tobacco; Toxin; Trace metal; Training; Translating; Translational Research; United States; United States Department of Veterans Affairs; Universities; Work; Zinc deficiency; adduct; alcohol effect; alcohol misuse; alcohol research; animal tissue; cell injury; cigarette smoking; clinical translation; college; comorbidity; human tissue; insight; lifestyle factors; liver injury; member; metal metabolism; multidisciplinary; multiorgan damage; novel; pathogen; problem drinker; protein transport; recruit; symposium; tissue injury; training opportunity

The goal of the Alcohol Center of Research-Nebraska (ACORN) is to expand existing strengths and expertise in Nebraska to develop a novel niche in alcohol research, by creating a Center focused on the Alcohol Exposome. Alcohol research has been a major area of emphasis in Nebraska (at the Omaha VA Medical Center Research Service and at the University of Nebraska Medical Center) for over 5 decades. As a result, many contributions to the field of alcohol research and the treatment of alcoholic liver disease have been made. Studies examining the effects of alcohol on trace metal metabolism, lung biology and physiology, mechanisms of alcoholic fatty liver, role of aldehyde adducts in alcoholic cell injury, hepatic protein trafficking and signal transduction events and the role of immune mechanisms in alcoholic liver disease have been some of the key areas of investigation. Our goal is to translate to humans how factors in the exposome such as age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. We know that a major component of the specific external environment is the lifestyle factor of alcohol consumption. Thus, under the comprehensive schema of the exposome, alcohol represents an environmental exposure that should be considered in context with other internal and external factors to understand causes and nature of disease progression. The overall hypothesis of our application is the following: the examination of alcohol in the context of the exposome will allow us to understand its role more fully in the etiology of disease and the subsequent manifestations of alcohol-induced human pathophysiology. The alcohol-exposome theme of the center is unique among alcohol centers and has the potential to be highly translational. Our investigators represent an outstanding team of interdisciplinary investigators that will be supported by an Administrative Core, a Biospecimen Core, and a Pilot Projects Core. ACORN investigators will have access to state-of-the art facilities at UNMC, Nebraska Medical Center and University of Nebraska-Lincoln. We include faculty from 5 departments and 3 colleges. Our proposed Specific Aims for the ACORN are to: 1) Facilitate interdisciplinary research and identify factors so that we can translate in humans how age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. 2) Create a Biospecimen Core to aid Center investigators in promotion and development of translational animal and human tissue and cell models. 3) Enhance the collaborative ACORN environment and provide opportunities for funding through training, symposia, and pilot grants. Work on our 4 research projects, with participation of the Administration Core and the Biospecimen Core will allow us to realize our goals. Overall, this new P50 will utilize the expertise and knowledge of past research efforts to examine how alcohol, in the setting of various external and internal environmental factors will influence disease in a variety of organs and help us shape our future animal and human studies.

内布拉斯加州酒精研究中心的目标是扩大现有的优势和专业知识 在内布拉斯加州，通过创建一个专注于酒精研究的中心， 暴露体酒精研究一直是内布拉斯加州的一个主要重点领域（在奥马哈退伍军人管理局医疗中心 中心研究服务和内布拉斯加大学医学中心）超过50年。因此，在本发明中， 对酒精研究和酒精性肝病治疗领域的许多贡献， 进行了研究酒精对微量金属代谢、肺生物学和生理学的影响， 酒精性脂肪肝机制，醛加合物在酒精性细胞损伤中的作用，肝蛋白转运 信号转导事件和免疫机制在酒精性肝病中的作用已经有了一些 调查的关键领域。我们的目标是向人类解释， 营养状况、吸烟和暴露于病原体在有或无酒精的情况下相互作用 局我们知道，特定外部环境的一个主要组成部分是生活方式因素， 酒精消费。因此，在麻烦的综合图式下，酒精代表了一种 环境暴露应与其他内部和外部因素一起考虑， 了解疾病进展的原因和性质。我们的应用程序的总体假设是 以下：在麻烦的背景下检查酒精将使我们了解其作用 更充分地在病因和酒精引起的人类随后的表现 病理生理学该中心的酒精困扰主题在酒精中心中是独一无二的， 具有高度转化的潜力。我们的研究人员代表了一支优秀的跨学科团队， 研究者将由一个行政核心、一个生物标本核心和一个试点项目核心提供支持。 ACORN的调查人员将可以使用UNMC、内布拉斯加州医疗中心和 内布拉斯加大学林肯分校。我们包括来自5个部门和3个学院的教师。我们的建议具体 ACORN的目标是：1）促进跨学科研究并确定因素，以便我们能够翻译 在人类中，年龄、营养状况、吸烟和暴露于病原体如何在存在 或不给予酒精。2)创建生物样本核心，以帮助中心研究者进行推广 以及转化动物和人类组织和细胞模型的开发。3)加强协作 ACORN环境，并通过培训，研讨会和试点赠款提供资助的机会。工作 在我们的4个研究项目中，在行政核心和生物标本核心的参与下， 来实现我们的目标总的来说，这种新的P50将利用过去研究工作的专业知识和知识， 研究酒精如何在各种外部和内部环境因素的背景下影响疾病 帮助我们塑造未来的动物和人类研究。