Atomically precise, multi-ligand functionalised metal nanoclusters to combat bacterial antibiotic resistance
原子精确的多配体功能化金属纳米簇可对抗细菌抗生素耐药性
基本信息
- 批准号:2882405
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Bacterial antibiotic resistance (BAR) is "one of the biggest threats to global health". While traditional antibiotic discovery is valuable, it is lengthy, expensive, and moreover, rapid BAR is inevitable once in clinical use, due to evolutionary adaptation of bacteria to antibiotic actions. Whereas nanomaterials can offer several antibacterial modes in one agent, making it much harder for bacteria to develop resistance. Some nanomaterials can re-vitalise antibiotics against multidrug resistant bacteria, thus can offer a cheaper, faster and robust alternative to antibiotics to address BAR challenge. Despite great advance, most researches are focused on improving nanomaterials' in vitro antibacterial potencies with little consideration of translation. To date, most antibacterial nanomaterials remain mixed size particles without defined chemical formula, and exhibit limited in vivo stability, biocompatibility and undesirable body clearance. These have greatly limited their potential for clinical translation. We will address such issues by developing atomically precise, multi-ligand functionalised M25 nanoclusters (NCs). We target the M25SR18 NC (SR = thiol ligand) owing to high stability, well-defined molecular structure, and facile synthesis method. We will engineer NCs with excellent stability, biocompatibility and antibacterial potency via multi-functional ligand coating (each for antibacterial potency, in vivo stability & targeting). We will directly track NC-cell interactions, intracellular trafficking and bio-distribution via NC's strong NIR fluorescence. We will evaluate NCs' antibacterial properties using bacteria culture and biofilm models with & without antibiotics to probe potential synergy and establish surface-structure-function relationships and a design rule for antibiotic NCs.
细菌抗生素耐药性(BAR)是“对全球健康的最大威胁之一”。虽然传统的抗生素发现是有价值的,但它是漫长的,昂贵的,而且,由于细菌对抗生素作用的进化适应,一旦在临床使用中,快速BAR是不可避免的。而纳米材料可以在一种药剂中提供多种抗菌模式,使细菌更难产生耐药性。一些纳米材料可以重新激活抗生素对抗多重耐药细菌,从而可以提供更便宜,更快和更强大的抗生素替代品来应对BAR挑战。尽管纳米材料的研究取得了很大进展,但大多数研究都集中在提高纳米材料的体外抗菌能力上,很少考虑纳米材料的翻译。到目前为止,大多数抗菌纳米材料仍然是混合尺寸的颗粒,没有明确的化学式,并表现出有限的体内稳定性,生物相容性和不良的身体清除。这极大地限制了其临床转化的潜力。我们将通过开发原子精确的多配体官能化M25纳米团簇(NC)来解决这些问题。我们的目标是M25 SR 18 NC(SR =硫醇配体),由于其高稳定性,明确的分子结构和简便的合成方法。我们将通过多功能配体涂层(每种用于抗菌效力,体内稳定性和靶向)设计具有优异稳定性,生物相容性和抗菌效力的NC。我们将通过NC的强NIR荧光直接跟踪NC-细胞相互作用、细胞内运输和生物分布。我们将使用细菌培养和生物膜模型评估NCs的抗菌特性,使用和不使用抗生素,以探索潜在的协同作用,并建立表面结构功能关系和抗生素NCs的设计规则。
项目成果
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其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
- DOI:
10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
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Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
- 影响因子:4.5
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The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
- 影响因子:3.4
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ElasticBLAST: accelerating sequence search via cloud computing.
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10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
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Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
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- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
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{{ truncateString('', 18)}}的其他基金
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