NIR-Emissive Polymersomal Markers for Molecula-Level Detection of Metastasis
用于分子水平转移检测的近红外发射聚合物标记物
基本信息
- 批准号:7477325
- 负责人:
- 金额:$ 28.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-01 至 2010-07-31
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAnimal ModelAnimalsAntibodiesBenchmarkingBindingBiocompatibleBiologicalBiologyBiomedical EngineeringBloodBlood VesselsButadieneCaliberCarcinomaCell AdhesionCell CountCell surfaceCellsChemicalsClinicalConditionConfocal MicroscopyCoupledCouplingDataDepthDetectionDiagnosisDiagnosticDiseaseDisseminated Malignant NeoplasmDrug Delivery SystemsEarly DiagnosisEngineeringEthylene OxideEvaluationEvolutionFab ImmunoglobulinsFamilyFlow CytometryFluorescenceFoundationsGenerationsGoalsHeadImageIn VitroLabelLifeLigand BindingLocalizedLungMalignant NeoplasmsMeasurableMeasuresMechanicsMediatingMedicalMedicineMembraneMethodsMicroscopicModelingModificationMolecularMono-SNCI Unconventional Innovations ProgramNanotechnologyNatureNeoplasm MetastasisNormal CellNumbersOpticsOutputPenetrationPeptidesPolymersPopulationPorphyrinsPrincipal InvestigatorProceduresPropertyProteinsProtocols documentationReactionResidual TumorsSignal TransductionSolutionsSonStreamStructureSurfaceSystemTechnologyTestingThickTimeTissue ModelTissuesTumor TissueVesicleWorkantibody conjugateaqueousarteriolebasebioimagingcancer cellcaprolactonecellular targetingchemical propertychemical synthesischromophoreclinically relevantcopolymerdesigndi-block copolymerengineering designfluorophorefunctional groupin vivoin vivo Modelinsightmembernanonanoscaleneoplastic celloptical imagingphysical propertypolyethylene oxide-polycaprolactone copolymerporphyrin structureprogramsprototypequantumreceptorresearch studyself assemblytissue culturetooltumor
项目摘要
DESCRIPTION (provided by applicant): The detection of early carcinoma or dormant or latent metastatic tumor cells remains an elusive but important clinical goal. We seek to develop further revolutionary new nanotechnology that enables optically based detection of metastatic cancer cells. Towards this goal, we will further refine design criteria for near infrared (NIR) emissive polymersomes, a promising new soft matter nanoscale platform for in vivo diagnostic and drug-delivery applications. This program will develop (i) targeted nanoscale (diameter < 100 nm) NIR- emissive polymersomes, (ii) nanoscale NIR-emissive polymersomes having optimized emissive output, (iii) prototype targeted nanoscale vesicles in which the polymeric building blocks are based-upon FDA-approved materials, (iv) targeted NIR-emissive polymersomes with ideal cell-surface adhesion dynamics, and (v) methods and technology that provide not only new insights into metastatic disease, but define an evolvable nanoscale platform for in vivo dormant tumor cell detection, diagnosis, and treatment. These efforts involve correlating NIR fluorophore structure and photophysics, polymersome composition of matter, vesicle mechanical and biological properties, nanoscale NIR-emissive polymersome fluorescence output, and the nature of the cellular targeting motif, with in vivo function and efficacy. As such, the experimental approach we pursue is cross-cutting and integrative, encompassing supramolecular chemical synthesis, photophysical characterization, in vivo imaging, bioengineering, biology, and medicine. We will strive to establish design principles that will ultimately enable real-time detection and identification of limited target cell numbers under clinically relevant diagnostic conditions, and define new tools for the study of metastatic disease.
描述(由申请人提供):检测早期癌症或潜伏或潜伏的转移肿瘤细胞仍然是一个难以捉摸但重要的临床目标。我们寻求进一步开发革命性的新纳米技术,使基于光学的检测转移的癌细胞成为可能。为了实现这一目标,我们将进一步完善近红外(NIR)发射聚合体的设计标准,这是一种很有前途的新的软物质纳米级平台,用于体内诊断和药物输送应用。该计划将开发(I)靶向纳米级(直径100 nm)近红外发射聚合体,(Ii)具有优化发射输出的纳米级近红外发射聚合体,(Iii)其中聚合构建块基于FDA批准的材料的靶向纳米囊泡,(Iv)具有理想细胞表面黏附动力学的靶向近红外发射聚合体,以及(V)不仅为转移疾病提供新的见解,而且定义了用于体内潜伏肿瘤细胞检测、诊断和治疗的可进化纳米级平台的方法和技术。这些努力包括近红外荧光团结构和光物理、物质的聚合体组成、囊泡的机械和生物学特性、纳米尺度的近红外发射聚合体荧光输出以及细胞靶向基序的性质与体内功能和有效性的关联。因此,我们追求的实验方法是交叉和综合的,包括超分子化学合成、光物理表征、活体成像、生物工程、生物学和医学。我们将努力建立设计原则,最终能够在临床相关的诊断条件下实时检测和识别有限的靶细胞数量,并为转移疾病的研究定义新的工具。
项目成果
期刊论文数量(0)
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MICHAEL J THERIEN其他文献
MICHAEL J THERIEN的其他文献
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{{ truncateString('MICHAEL J THERIEN', 18)}}的其他基金
PHOTOPHYSICAL STUDIES OF CONJUGATED MULTIPORPHYRIN COMPOUNDS
共轭多卟啉化合物的光物理研究
- 批准号:
7955454 - 财政年份:2009
- 资助金额:
$ 28.66万 - 项目类别:
TRANSIENT IR STUDIES OF PROTON COUPLED ELECTRON TRANSFER
质子耦合电子转移的瞬态红外研究
- 批准号:
7955434 - 财政年份:2009
- 资助金额:
$ 28.66万 - 项目类别:
DESIGN AND ELABORATION OF A PHOTO-ACTIVATABLE DE NOVO PROTEIN
光激活从头蛋白的设计和制备
- 批准号:
7723847 - 财政年份:2008
- 资助金额:
$ 28.66万 - 项目类别:
TRANSIENT IR STUDIES OF PROTON COUPLED ELECTRON TRANSFER
质子耦合电子转移的瞬态红外研究
- 批准号:
7723843 - 财政年份:2008
- 资助金额:
$ 28.66万 - 项目类别:
PHOTOPHYSICAL STUDIES OF CONJUGATED MULTIPORPHYRIN COMPOUNDS
共轭多卟啉化合物的光物理研究
- 批准号:
7723865 - 财政年份:2008
- 资助金额:
$ 28.66万 - 项目类别:
INTRAMOLECULAR ELECTRON TRANSFER IN PORPHYRIN DIMERS, TIMERS AND PENTAMERS
卟啉二聚体、定时器和五聚体中的分子内电子转移
- 批准号:
7598444 - 财政年份:2007
- 资助金额:
$ 28.66万 - 项目类别:
PHOTOPHYSICAL STUDIES OF CONJUGATED MULTIPORPHYRIN COMPOUNDS
共轭多卟啉化合物的光物理研究
- 批准号:
7598441 - 财政年份:2007
- 资助金额:
$ 28.66万 - 项目类别:
PUMP-PROBE SPECTROSCOPY OF PROTON-COUPLED ELECTRON TRANSFER IN PROTEINS
蛋白质中质子耦合电子转移的泵探针光谱
- 批准号:
7598439 - 财政年份:2007
- 资助金额:
$ 28.66万 - 项目类别:
COHERENT PHENOMENA IN ULTRAFAST BIOLOGICAL PROCESSES
超快生物过程中的连贯现象
- 批准号:
7373135 - 财政年份:2006
- 资助金额:
$ 28.66万 - 项目类别:
NIR-Emissive Polymersomal Markers for Molecula-Level Detection of Metastasis
用于分子水平转移检测的近红外发射聚合物标记物
- 批准号:
7673559 - 财政年份:2006
- 资助金额:
$ 28.66万 - 项目类别:
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