TRANSIENT IR STUDIES OF PROTON COUPLED ELECTRON TRANSFER

质子耦合电子转移的瞬态红外研究

• 批准号: 7723843
• 负责人: MICHAEL J THERIEN
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723843
• 关键词: Arts; Binding; Computer Retrieval of Information on Scientific Projects Database; Coupled; Electron Transport; Electrostatics; Engineering; Funding; Grant; Institution; Link; Methodology; Methods; Molecular; Optics; Protons; Pump; Reaction; Research; Research Personnel; Resources; Source; Spectrum Analysis; Structure; Structure-Activity Relationship; System; Time; United States National Institutes of Health; Work; cofactor; instrumentation; nanosecond; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The types of dynamics-correlated experiments that we intend to pursue will utilize state-of-the-art experimental methodologies and instrumentation to study molecular transient spectroscopy on fast, sub-nanosecond time scales. Optical pump-probe, optical-pump/infrared-probe and dynamics Stokes shift experiments will be correlated with experiments such as transient optical pump-probe experiments. This work will delineate structure-function relationships engineered to bind donor - spacer - acceptor (D-Sp-A) supermolecules and covalently linked multi-cofactor assemblies. While these systems possess reduced structural complexity, they enable independent modulation of the local electrostatic forces that surround D and A. We will examine photoinduced PCET reactions in such systems using optical pump / optical probe and visible pump / IR probe spectroscopic methods, and correlate the observed dynamics with specific responses with specific structures.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们打算进行的动力学相关实验类型将利用最先进的实验方法和仪器来研究快速、亚纳秒时间尺度的分子瞬态光谱。光泵浦探针、光泵/红外探针和动态斯托克斯位移实验将与瞬态光泵浦探针实验等实验相关联。 这项工作将描述设计用于结合供体-间隔基-受体（D-Sp-A）超分子和共价连接的多辅因子组装体的结构-功能关系。 虽然这些系统的结构复杂性降低，但它们能够独立调制 D 和 A 周围的局部静电力。我们将使用光泵/光学探针和可见光泵/红外探针光谱方法检查此类系统中的光诱导 PCET 反应，并将观察到的动力学与特定结构的特定响应相关联。