DESIGN AND ELABORATION OF A PHOTO-ACTIVATABLE DE NOVO PROTEIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 作为迈克尔·J·塞里安教授、杰弗里·G·塞林教授和迈克尔·塞林教授合作的一部分，Saven和William F. DeGrado，我们产生四螺旋蛋白束能够结合具有锌二苯基卟啉（DPP）Zn部分的光活化无机复合物。 这些蛋白质/发色团系统经历光引发的电子/能量转移过程，并表现出优异的非线性光学性质。 作为光动力学表征的一部分，我们利用Nd：YAG激光系统在区域激光和生物医学技术实验室（RLBL）测量的三重激发态过程的各种蛋白质/生色团复合物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As part of a collaboration between Professors Michael J. Therien, Jeffrey G. Saven, and William F. DeGrado, we generate four-helix protein bundles capable of binding photoactivateable inorganic complexes that possess zinc diphenyl porphyrin, (DPP)Zn moieties. These protein/chromophore systems undergo photoinitiated electron/energy transfer processes and exhibit excellent non-linear optic properties. As part of the characterization of the photodynamics, we utilize the Nd:YAG laser system in the Regional Laser and Biomedical Technologies Laboratories (RLBL) for measuring the triplet excited state processes of the various protein/chromophore complexes.