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Exercise and Quality of Life in Severely Burned Children

严重烧伤儿童的运动和生活质量

基本信息

批准号：
7483265
负责人：
Oscar E. Suman-Vejas
金额：
$ 26.58万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7483265
关键词：
18 year old Acute Aerobic Aerobic Exercise Affect Age Alanine Applications Grants Body Composition Body Surface Area Body measure procedure Burn injury Cardiopulmonary Caring Catabolism Characteristics Child Child health care Clinical Collection Contracture Data Doctor of Philosophy Education Environment Equilibrium Equipment and supply inventories Exercise Exercise stress test Future Grant Guidelines Health Home environment Hospitals Hour Ingestion Instruction Joints Knowledge Lead Leg Living Wills Medical Motivation Muscle Numbers Occupational Therapy Operative Surgical Procedures Outcome Outcome Measure Patient Discharge Patients Pediatric Hospitals Physical Function Physiological Process Protein Biosynthesis Proteins Purpose Quality of life Questionnaires Randomized Rehabilitation therapy Reporting Research Personnel Resistance Roentgen Rays Skeletal Muscle Standards of Weights and Measures Structure Testing Time Training Urea Urine Week Writing bone clinical application clinically relevant day improved muscle strength novel programs psychosocial psychosocial rehabilitation response

项目摘要

DESCRIPTION (provided by applicant): The current Standard of Care for the rehabilitation of severely burned children is to discharge the patient from the hospital, with a written set of instructions for physical and occupational therapy activities at home, in an unsupervised environment. These activities do not significantly impact the persistent and extensive skeletal muscle catabolism and weakness characteristic of severe burns. The central hypothesis of this grant is that a supervised anld structured aerobic and resistance exercise program implemented at hospital discharge in severely burned children will improve physical structure and function, allowing for an improvement in quality of life (QOL). We propose the following specific aims (SA): SA1 will test the hypothesis that in severely burned children, a supervised and structured exercise program will significantly increase muscle mass and bone mass more than the current Standard of Care. SA2 will test the hypothesis that in burned children, <p supervised and structured exercise program will significantly increase peak aerobic capacity and muscle strejngth more than the current Standard of Care. SA3 will test the hypothesis that a supervised and structure'd exercise program will significantly increase net protein synthesis compared to the current Standard of Care in burned children and lead to an improvement in lean mass and muscle strength. SA4 will test the hypothesis that in burned children, a supervised and structured exercise program will significantly improve QOL more than the current Standard of Care. Primary outcomes are peak aerobic capacity assessed with a. cardiopulmonary exercise test; muscle strength, using leg dynamometry, muscle mass assessed usingidual X-ray absorptiometry, and net protein balance assessed using urea enrichment. Finally, psychosocial health using the Child Health Questionnaire, (PF-28 and CF-87) will be assessed. Assessment of physical function, and QOL will be done at hospital discharge, at the end of the 12-week exercise program, at 12 months, and at 24 months post burn. Assessment of net protein balance will be done at hospital discharge, c^nd at the end of the 12-week exercise program. It is expected that these proposed studies will expand the present knowledge of physical and psychosocial rehabilitation programs for severely burned children. Furthermore, we believe that these proposed studies will result in novel and clinically relevant data that may jn turn establish new guidelines for the Standard of Care of burned children.

描述（由申请人提供）：目前严重烧伤儿童康复的护理标准是让患者出院，并在无人监督的环境中在家中进行一套书面的物理和职业治疗活动说明。这些活动不会显著影响严重烧伤的持久和广泛的骨骼肌分解代谢和虚弱特征。本资助的中心假设是，在严重烧伤儿童出院时实施有监督和有组织的有氧和抗阻运动计划，将改善身体结构和功能，从而提高生活质量（QOL）。我们提出以下具体目标（SA）： SA1将检验严重烧伤儿童的假设，一个有监督和有组织的锻炼计划将比目前的护理标准更能显著增加肌肉质量和骨量。SA2将检验假设，在烧伤儿童中，<p监督和有组织的运动计划将比目前的护理标准更显着提高峰值有氧能力和肌肉力量。SA3将测试一个假设，即与目前的烧伤儿童护理标准相比，一个有监督和有组织的锻炼计划将显著增加净蛋白质合成，并导致瘦质量和肌肉力量的改善。SA4将测试一个假设，即在烧伤儿童中，一个有监督和有组织的锻炼计划将比目前的护理标准更能显著改善生活质量。主要结局是通过心肺运动试验评估峰值有氧能力；肌肉力量用腿部测力仪测量，肌肉质量用单个x射线吸收仪评估，净蛋白质平衡用尿素富集法评估。最后，将使用儿童健康问卷（PF-28和CF-87）评估心理社会健康。身体功能和生活质量的评估将在出院时、12周运动计划结束时、烧伤后12个月和24个月进行。净蛋白质平衡的评估将在出院、c^和12周运动计划结束时进行。预计这些拟议的研究将扩大目前对严重烧伤儿童的身体和心理康复计划的了解。此外，我们相信这些拟议的研究将产生新的和临床相关的数据，可能反过来为烧伤儿童的护理标准建立新的指导方针。