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Exercise and Quality of Life in Severely Burned Children

严重烧伤儿童的运动和生活质量

基本信息

批准号：
8098793
负责人：
Oscar E. Suman-Vejas
金额：
$ 26.05万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8098793
关键词：
18 year old Acute Aerobic Aerobic Exercise Affect Age Alanine Applications Grants Body Composition Body Surface Area Burn injury Cardiopulmonary Catabolism Characteristics Child Child health care Clinical Collection Contracture Data Doctor of Philosophy Education Environment Equilibrium Equipment and supply inventories Exercise Exercise stress test Future Grant Guidelines Health Home environment Hospitals Hour Ingestion Instruction Joints Knowledge Lead Leg Medical Motivation Muscle Occupational Therapy Operative Surgical Procedures Outcome Outcome Measure Patient Discharge Patients Pediatric Hospitals Physical Function Physical therapy Physiological Process Protein Biosynthesis Proteins Quality of life Questionnaires Randomized Rehabilitation therapy Reporting Research Personnel Resistance Roentgen Rays Skeletal Muscle Structure Testing Time Training Urea Urine Writing bone mass clinical application clinically relevant improved muscle form muscle strength novel primary outcome programs psychosocial psychosocial rehabilitation response standard of care treatment strategy

项目摘要

DESCRIPTION (provided by applicant): The current Standard of Care for the rehabilitation of severely burned children is to discharge the patient from the hospital, with a written set of instructions for physical and occupational therapy activities at home, in an unsupervised environment. These activities do not significantly impact the persistent and extensive skeletal muscle catabolism and weakness characteristic of severe burns. The central hypothesis of this grant is that a supervised anld structured aerobic and resistance exercise program implemented at hospital discharge in severely burned children will improve physical structure and function, allowing for an improvement in quality of life (QOL). We propose the following specific aims (SA): SA1 will test the hypothesis that in severely burned children, a supervised and structured exercise program will significantly increase muscle mass and bone mass more than the current Standard of Care. SA2 will test the hypothesis that in burned children, <p supervised and structured exercise program will significantly increase peak aerobic capacity and muscle strejngth more than the current Standard of Care. SA3 will test the hypothesis that a supervised and structure'd exercise program will significantly increase net protein synthesis compared to the current Standard of Care in burned children and lead to an improvement in lean mass and muscle strength. SA4 will test the hypothesis that in burned children, a supervised and structured exercise program will significantly improve QOL more than the current Standard of Care. Primary outcomes are peak aerobic capacity assessed with a. cardiopulmonary exercise test; muscle strength, using leg dynamometry, muscle mass assessed usingidual X-ray absorptiometry, and net protein balance assessed using urea enrichment. Finally, psychosocial health using the Child Health Questionnaire, (PF-28 and CF-87) will be assessed. Assessment of physical function, and QOL will be done at hospital discharge, at the end of the 12-week exercise program, at 12 months, and at 24 months post burn. Assessment of net protein balance will be done at hospital discharge, c^nd at the end of the 12-week exercise program. It is expected that these proposed studies will expand the present knowledge of physical and psychosocial rehabilitation programs for severely burned children. Furthermore, we believe that these proposed studies will result in novel and clinically relevant data that may jn turn establish new guidelines for the Standard of Care of burned children.

描述(由申请人提供)：目前严重烧伤儿童康复护理的标准是在无人监督的环境中出院，并提供一套在家进行物理和职业治疗活动的书面指导。这些活动对严重烧伤的持续性和广泛性骨骼肌分解代谢和虚弱特征没有显著影响。这笔赠款的中心假设是，在严重烧伤儿童出院时实施有监督和结构化的有氧和阻力锻炼计划将改善身体结构和功能，从而提高生活质量(QOL)。我们提出了以下具体目标(SA)：SA1将检验这一假设，即在严重烧伤的儿童中，有监督和有组织的锻炼计划将显著增加肌肉质量和骨量，超过当前的护理标准。SA2将检验这一假设，即在烧伤儿童中，有监督和有组织的锻炼计划将显著提高峰值有氧能力和肌肉紧张度，超过当前的护理标准。SA3将测试这样一个假设，即与目前的护理标准相比，有监督和有结构的锻炼计划将显著增加烧伤儿童的净蛋白质合成，并导致瘦体重和肌肉力量的改善。SA4将检验这一假设，即在烧伤儿童中，有监督和有组织的锻炼计划将比目前的护理标准更显著地改善生活质量。主要结果是通过心肺运动试验评估最大有氧能力；使用腿部测力评估肌肉力量；使用X射线吸收计量仪评估肌肉质量；使用尿素富集法评估净蛋白质平衡。最后，将使用儿童健康问卷(PF-28和CF-87)对心理社会健康进行评估。在出院时、12周锻炼计划结束时、12个月时和烧伤后24个月时进行身体功能和生活质量评估。净蛋白质平衡的评估将在出院时进行，并在12周锻炼计划结束时进行。预计这些拟议的研究将扩大目前对严重烧伤儿童的身体和心理社会康复计划的了解。此外，我们相信这些拟议的研究将产生新的和临床相关的数据，这些数据可能会为烧伤儿童的护理标准建立新的指南。