Physiological Adaptations to Exercise in Burned Children

描述 (申请者摘要)苏曼博士的长期职业目标和兴趣是 了解心血管系统发生适应的机制(S)， 肺和骨骼肌系统对运动的反应。总的来说，他 展望自己在生理学领域建立科学研究生涯 并使用运动作为对抗功能性残疾的干预工具 疾病。他的直接职业目标包括研究对 发生在严重烧伤儿童身上的运动。目前，苏曼博士 建议在德克萨斯大学医学分校继续他的研究 和Shriners儿童医院，与大卫·N博士合作。 赫恩登，罗伯特·R·沃尔夫博士和丹尼尔·L·特拉伯博士。研究： 对严重烧伤的生理反应包括持续性和 广泛的骨骼肌分解代谢和导致体力低下的虚弱 容量。在非烧伤个体中，运动训练诱导的适应 包括改善心血管(CV)和肌肉功能。然而， 目前运动是否使烧伤儿童有这些适应能力 未知。更好地理解对运动训练的适应是 重要和相关的烧伤，其中心血管和 肌肉功能是恢复体力活动的主要障碍 日常生活。这项拟议的研究将检验这样的假设，即锻炼，在 严重烧伤的儿童，将通过增加 心功能，氧摄取和利用，以及骨骼肌质量。 具体目标1将评估CV和骨骼肌是否减少 严重烧伤儿童心脏功能受损 运动成绩和骨骼肌氧化功能及浓度降低 肌球蛋白重链。具体目标2将评估是否妥协 随着运动训练的进行，CV水平和肌肉功能都会得到改善。 具体目标3将评估给药合成代谢药 (奥昔洛酮)对烧伤儿童的锻炼效果会进一步增强 对CV和骨骼肌功能能力的影响。我们期待着这些具体目标 作为未来治疗和长期研究的跳板 烧伤儿童的康复。

DESCRIPTION (Applicant's abstract) Dr. Suman's long-term career goals and interests are to understand the mechanism(s) by which adaptations occur in the cardiovascular, pulmonary and skeletal muscle systems in response to exercise. Broadly, he foresees himself establishing a scientific investigative career in physiology and using exercise as an interventional tool against functional disability and disease. His immediate career goals involve investigating the adaptations to exercise that occur in severely burned children. Currently, Dr. Suman proposes to continue his research at the University of Texas Medical Branch and Shriners Hospitals for Children, in collaboration with Dr. David N. Herndon, Dr. Robert R. Wolfe and Dr. Daniel L. Traber. Research: The physiological response to a severe burn injury includes a persistent and extensive skeletal muscle catabolism and weakness that leads to a low physical capacity. In non-burn individuals, exercise training induces adaptations that include improvement of cardiovascular (CV) and muscle function. However, whether exercise confers these adaptions in burned children in currently unknown. A better understanding of the adaptations to exercise training is important and relevant in burns, where alterations in cardiovascular and muscle function are major obstacles in the return to physical activities of daily living. The proposed study will test the hypothesis that exercise, in severely burned children, will improve CV and muscle performance by increasing cardiac function, oxygen uptake and utilization, and skeletal muscle mass. Specific Aim 1 will assess whether decreases in CV and skeletal muscle function in severely burned children are due to compromised cardiac performance and skeletal muscle oxidative function and decreased concentration of myosin heavy chain. Specific Aim 2 will assess whether the compromised level of CV and muscle function will be improved with exercise training. Specific Aim 3 will assess whether administration of an anabolic agent (oxandrolone) to burned children will further enhance the effects of exercise on CV and skeletal muscle functional capacity. We expect these Specific Aims to serve as a springboard for future studies in the treatment and long-term rehabilitation of burned children.