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Exercise and Quality of Life in Severely Burned Children

严重烧伤儿童的运动和生活质量

基本信息

批准号：
8606222
负责人：
Oscar E. Suman-Vejas
金额：
$ 24.93万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8606222
关键词：
18 year old Acute Address Aerobic Aerobic Exercise Affect Age Alanine Applications Grants Asses Body Composition Body Surface Area Burn injury Cardiopulmonary Catabolism Characteristics Child Child health care Clinical Collection Contracture Data Education Environment Equilibrium Equipment and supply inventories Exercise Exercise stress test Future Grant Guidelines Health Home environment Hospitals Hour Ingestion Instruction Joints Knowledge Lead Leg Medical Motivation Muscle Occupational Therapy Operative Surgical Procedures Outcome Outcome Measure Patient Discharge Patients Pediatric Hospitals Physical Function Physical Rehabilitation Physical therapy Physiological Process Protein Biosynthesis Proteins Quality of life Questionnaires Randomized Rehabilitation therapy Reporting Resistance Roentgen Rays Skeletal Muscle Structure Testing Time Training Urea Urine Writing bone mass clinical application clinically relevant improved muscle form muscle strength novel primary outcome programs psychosocial psychosocial rehabilitation response standard of care treatment strategy

项目摘要

The current Standard of Care for the rehabilitation of severely burned children is to discharge the patientfrom the hospital, with a written set of instructions for physical and occupational therapy activities at home, in an unsupervised environment. These activities do not significantly impact the persistent and extensive skeletal muscle catabolism and weakness characteristic of severe burns. The central hypothesis of this grant is that a supervised and structured aerobic and resistance exercise program implemented at hospital discharge in severely burned children will improve physical structure and function, allowing for an improvement in quality of life (QOL). We propose the following specific aims (SA): SA1 will test the hypothesis that in severely burned children, a supervised and structured exercise program will significantly increase muscle mass and bone mass more than the current Standard of Care. SA2 will test the hypothesis that in burned children, a supervised and structured exercise program will significantly increase peak aerobic capacity and muscle strength more than the current Standard of Care. SA3 will test the hypothesis that a supervised and structured exercise program will significantly increase net protein synthesis compared to the current Standard of Care in burned children and lead to an improvement in lean mass and muscle strength. A4 will test the hypothesis that in burned children, a supervised and structured exercise program will significantly improve QOL more than the current Standard of Care. Primary outcomes are peak aerobic capacity assessed with a cardiopulmonary exercise test; muscle strength, using leg dynamometry, muscle ass assessed using dual X-ray absorptiometry, and net protein balance assessed using urea enrichment. Finally, psychosocial health using the Child Health Questionnaire, (PF-28 and CF-87) will be assessed. Assessment of physical function, and QOL will be done at hospital discharge, at the end of the 12-week exercise program, at 12 months, and at 24 months post burn. Assessment of net protein balance will be done at hospital discharge, and at the end of the 12-week exercise program. It is expected that these proposed studies will expand the present knowledge of physical and psychosocial rehabilitation programs for severely burned children. Furthermore, we believe that these proposed studies will result in novel and clinically relevant data that may in turn establish new guidelines for the Standard of Care of burned children.

目前严重烧伤儿童康复的护理标准是让患者出院，并附上一套在无人监督的环境下在家中进行物理和职业治疗活动的书面说明。这些活动不会显着影响持续和广泛的骨骼肌分解代谢以及严重烧伤的虚弱特征。这笔赠款的中心假设是，在严重烧伤儿童出院时实施的有监督和结构化的有氧运动和抗阻运动计划将改善身体结构和功能，从而提高生活质量（QOL）。我们提出以下具体目标 (SA)：SA1 将检验以下假设：对于严重烧伤的儿童，有监督和结构化的锻炼计划将比当前的护理标准显着增加肌肉质量和骨质量。 SA2 将检验以下假设：对于烧伤儿童来说，有监督的结构化锻炼计划将比当前的护理标准显着提高峰值有氧能力和肌肉力量。 SA3 将检验以下假设：与烧伤儿童目前的护理标准相比，有监督和结构化的锻炼计划将显着增加净蛋白质合成，并导致瘦体重和肌肉力量的改善。 A4 将检验以下假设：对于烧伤儿童来说，有监督的结构化锻炼计划将比当前的护理标准显着改善生活质量。主要结果是通过心肺运动测试评估峰值有氧能力；使用腿部测力法评估肌肉力量，使用双 X 射线吸收测定法评估肌肉屁股，并使用尿素浓缩评估净蛋白质平衡。最后，将使用儿童健康问卷（PF-28 和 CF-87）评估社会心理健康。身体功能和生活质量评估将在出院时、12 周锻炼计划结束时、烧伤后 12 个月和 24 个月时进行。净蛋白质平衡评估将在出院时和 12 周锻炼计划结束时进行。预计这些拟议的研究将扩大目前对严重烧伤儿童的身体和心理康复计划的了解。此外，我们相信这些拟议的研究将产生新颖的临床相关数据，从而可能为烧伤儿童的护理标准制定新的指南。