MR SPECTROSCOPY OF TUMORS & SURROUNDING TISSUE IN ABDOMEN OR PELVIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this study are to precisely identify the metabolites present in renal cell carcinoma (RCC) compared to normal renal tissue utilizing proton MRS, to determine if there is a specific metabolic fingerprint that differentiates RCC from benign tumors such as oncocytoma, and angiomyolipoma, and from other malignant lesions such as lymphoma, transitional cell carcinoma, and metastasis; and to determine if there is a correlation between the MRS and the histologic grade, stage, size of tumor and metastatic potential independent of stage and grade.