MR SPECTROSCOPY OF TUMORS & SURROUNDING TISSUE IN ABDOMEN OR PELVIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的具体目的是利用质子MRS精确识别肾细胞癌（RCC）与正常肾组织中的代谢物，以确定是否存在特异性代谢指纹，将RCC与良性肿瘤（如癌细胞瘤、血管平滑肌脂肪瘤）以及其他恶性病变（如淋巴瘤、移行细胞癌和转移）区分开来；并确定MRS与肿瘤的组织学分级、分期、大小和独立于分期和分级的转移潜力之间是否存在相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this study are to precisely identify the metabolites present in renal cell carcinoma (RCC) compared to normal renal tissue utilizing proton MRS, to determine if there is a specific metabolic fingerprint that differentiates RCC from benign tumors such as oncocytoma, and angiomyolipoma, and from other malignant lesions such as lymphoma, transitional cell carcinoma, and metastasis; and to determine if there is a correlation between the MRS and the histologic grade, stage, size of tumor and metastatic potential independent of stage and grade.