EFFECTS OF SREBP 1C OVEREXPRESSION IN FAT ON LIVER METABOLISM

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Liver flux profiling (LFP), based upon nuclear magnetic resonance (NMR) isotopomer analysis, has been applied in mice, rats and humans yet little is known about the sensitivity of this technique to controlled changes in hepatic physiology. Two subprojects are underway. First, the aP2-SREBP-1c transgenic mouse over expresses a truncated nuclear version of the sterol regulatory element binding protein-1c (SREBP-1c) in adipose tissue. Overexpression of this protein results in the upregluation of the enzymes involved in fatty acid synthesis. Second, we are examining the effects of redox state on pathways of hepatic glucose production.