TASK FORCE FOR OBESITY RESEARCH AT SOUTHWESTERN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 达拉斯的德克萨斯大学西南医学中心组建了四个团队，专注于美国的一个主要医疗问题--肥胖和代谢综合征。该项目创建了一种机制，将不同的研究人员小组聚集在一起，调查导致肥胖和代谢综合征的行为、代谢和分子事件。这项工作的主要重点将是大脑和肝脏，这两个器官在肥胖的发展及其不利的新陈代谢后果中都发挥着核心作用。我们的目标是更好地了解大脑是如何调节食物摄入和能量消耗的，并揭示肝脏中葡萄糖和脂肪代谢的失调是如何导致代谢综合征的发展的。为了实现这些目标，我们建立了四个研究团队，他们的方法和专业知识各不相同，将广泛互动，以追求这个项目的共同目标。调查人员之间的合作将在两个层面上进行。在每个团队内部，调查人员之间的广泛交流将促进直接的合作努力。四个主要小组之间还将进行互动，以利用四个小组中每个小组的不同专门知识，并为我们的主要目标提供全面的方法。这四个小组是：小组1：能量代谢的中央调节器(首席研究员，Keith Parker)；小组2：能量代谢的分子生物学(首席研究员，Jay D.Horton)；小组3：体内中间代谢(首席研究员，Craig Malloy)；以及小组4：人类遗传学和能量代谢(首席研究员，Scott Grundy)。在接下来的三年里，主要目标将是：1)在德克萨斯大学西南分校开发一个促进跨学科互动的计划，以研究肥胖和代谢综合征；2)开发一个最先进的计划，利用转基因小鼠阐明肥胖和代谢综合征的代谢和分子基础；以及3)支持将动物模型中的科学发现转化为人类。这项研究利用研究资源对人体血浆样本进行2H和13C核磁共振。它在这里被归类为服务项目，因为光谱仪的实际使用是由杰夫·布朗宁博士指导的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. UT Southwestern Medical Center at Dallas has assembled four teams to focus on a major medical problem in the U.S. - obesity and the metabolic syndrome. This project has created mechanisms to bring together diverse groups of investigators to investigate the behavioral, metabolic, and molecular events that cause obesity and the metabolic syndrome. The major focus of this effort will be on the brain and liver, organs that both play central roles in the development of obesity and its adverse metabolic consequences. Our goals are to better understand how the brain regulates food intake and energy expenditure and to reveal how dysregulation of glucose and lipid metabolism in the liver contributes to the development of the metabolic syndrome. To address these objectives, we have developed four research teams that vary in approaches and expertise that will interact extensively to pursue the shared goals of this project. Collaborations among investigators will occur on two levels. Within each team, extensive exchanges between investigators will foster direct collaborative efforts. Interactions will also occur between the four major teams to capitalize on the diverse expertise within each of the four groups and to provide comprehensive approaches to our major objectives. These four teams are: Team 1: Central Regulators of Energy Metabolism (Lead Investigator, Keith Parker); Team 2: Molecular Biology of Energy Metabolism (Lead Investigator, Jay D. Horton); Team 3: In Vivo Intermediary Metabolism (Lead Investigator, Craig Malloy) and Team 4: Human Genetics and Energy Metabolism (Lead Investigator, Scott Grundy). Over the next three years, the major objectives will be to: 1) develop a program to foster interdisciplinary interactions at UT Southwestern to study obesity and the metabolic syndrome; 2) develop a state-of-the-art program to elucidate the metabolic and molecular basis of obesity and the metabolic syndrome using genetically modified mice; and 3) support the translation of scientific findings made in animal models to humans. This study uses the Research Resource for the 2H and 13C NMR of plasma samples from humans. It is classified here as a service project because the actual use of the spectrometers is directed by Dr. Jeff Browning.