FD-NIRS IN THE BRAIN: CEREBRAL HEMODYNAMICS AND OXYGENATION

大脑中的 FD-NIRS：脑血流动力学和氧合

• 批准号: 7357990
• 负责人: ENRICO GRATTON
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-29 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357990
• 关键词: X ray; birth; brain; complement; fasting; fingers; hemodynamics; hypoxia; infrared spectrometry; ischemia; lighting; oxygen; root; sleep apnea; tissues; ultrasound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of our lab's research is to truly understand the underlying physics of light propagation in turbid media and then use the information to investigate brain tissue function during stimulation (finger tapping, etc.) and during disease (ADHD, sleep apnea, etc.). Our frequency-domain (intensity modulated) NIR spectrometers are fast, realtively inexpensive, technically simple, and most importantly, non-invasive and non-ionizing (safe). Our probes also possess novel contrast mechanisms that complement those of X-Ray, ultrasound, and MRI. The purpose of my research is to combine the use of NIR spectroscopy and other modalities in functional imaging in order to study the pathological processes of diseases that are rooted in oxygen deprivation via hypoxia and ischemia. Since we measure oxygen delivery and consumption in tissues, my aim is to develop the potential of NIRS into a screening and diagnostic clinical tool.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们实验室研究的目的是真正了解光在混浊介质中传播的基本物理学，然后利用这些信息来研究刺激（手指敲击等）过程中的脑组织功能。以及疾病期间（多动症、睡眠呼吸暂停等）。我们的频域（强度调制）近红外光谱仪快速、相对便宜、技术简单，最重要的是，无创和非电离（安全）。我们的探头还具有新颖的对比机制，可与X射线、超声和MRI的对比机制互补。我的研究目的是联合收割机在功能成像中使用近红外光谱和其他模式，以研究通过缺氧和缺血导致的缺氧疾病的病理过程。由于我们测量组织中的氧气输送和消耗，因此我的目标是将NIRS的潜力开发为筛查和诊断临床工具。