MULTIMODAL SPECTROSCOPY PROBE DEVELOPMENT

多模态光谱探头开发

• 批准号: 7357932
• 负责人: OBRAD SCEPANOVIC
• 金额: $ 4.07万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357932
• 关键词: lighting

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are investigating the utility of combining diagnostic information from reflectance and fluorescence to that obtained by Raman spectroscopy to diagnose atherosclerosis. As a result, a single spectral probe is being developed to be used with all three modalities. The combined probe would take excitation light from existing clinical FastEEM and Raman sources, deliver and collect the light from the tissue from a single source point. The combined probe is designed to be capable of delivering and collecting light in the 300-1000 nm spectral range. Based on the in vivo Raman probe that has been successful used in the surgical theatre, the combined probe will utilize a single tapered excitation fiber to couple the different light sources, incorporate excitation and emission filters with specially designed optical coatings to suppress fiber background and enable efficient extraction of the desired signal. Collection fibers would be split up and be directed to the two clinical systems for spectral analysis and parameter extraction.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们正在研究将反射和荧光的诊断信息与拉曼光谱的诊断信息结合起来诊断动脉粥样硬化的效用。因此，正在开发一种单光谱探针，用于所有三种模式。该组合探针将从现有的临床fastem和拉曼光源中获取激发光，从单个光源点传递和收集来自组织的光。该组合探针被设计成能够传输和收集300-1000纳米光谱范围内的光。基于已成功应用于手术室的体内拉曼探针，组合式探针将利用单个锥形激发光纤耦合不同的光源，结合具有特殊设计的光学涂层的激发和发射滤波器来抑制光纤背景，并能够有效地提取所需的信号。收集的纤维将被分离，并被引导到两个临床系统进行光谱分析和参数提取。