MULTIMODAL SPECTROSCOPY PROBE DEVELOPMENT

多模态光谱探头开发

• 批准号: 7600879
• 负责人: OBRAD SCEPANOVIC
• 金额: $ 4.69万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600879
• 关键词: Atherosclerosis; Clinical; Collection; Computer Retrieval of Information on Scientific Projects Database; Coupling; Development; Diagnosis; Diagnostic; Fiber; Fluorescence; Funding; Grant; Institution; Light; Location; Modality; Operative Surgical Procedures; Optics; Raman Spectrum Analysis; Range; Research; Research Personnel; Resources; Signal Transduction; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; base; design; desire; in vivo; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are investigating the utility of combining diagnostic information from reflectance and fluorescence to that obtained by Raman spectroscopy  termed multimodal spectroscopy (MMS) - to diagnose atherosclerosis and breast cancer. As a result, a single spectral probe is being developed to be used with all three modalities. The combined probe would take excitation light from existing clinical FastEEM and Raman sources and deliver to and collect the light from the same tissue location. The combined probe is designed to be capable of delivering and collecting light in the 300-1000 nm spectral range. Based on the in vivo Raman probe that has been successful used in the surgical theatre, the combined probe will enable the coupling of multiple sources into its single excitation fiber, incorporate excitation and emission filters with specially designed optical coatings to suppress fiber background and enable efficient extraction of the desired signal. Collection fibers would be split up and be directed to two spectrograph/CCD modules for spectral analysis and parameter extraction.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们正在研究将反射率和荧光的诊断信息与拉曼光谱（称为多模态光谱 (MMS)）获得的诊断信息结合起来的实用性，以诊断动脉粥样硬化和乳腺癌。因此，正在开发一种可与所有三种模式一起使用的单一光谱探头。组合探针将从现有的临床 FastEEM 和拉曼光源获取激发光，并将光传送到同一组织位置并收集来自同一组织位置的光。组合探头设计能够传输和收集 300-1000 nm 光谱范围内的光。基于已在外科手术中成功使用的体内拉曼探头，组合探头将能够将多个源耦合到其单个激发光纤中，将激发和发射滤光片与专门设计的光学涂层结合起来，以抑制光纤背景并能够有效提取所需信号。收集光纤将被分开并引导至两个光谱仪/CCD 模块以进行光谱分析和参数提取。