OPTICAL FIBER PROBE FOR BIOMEDICAL RAMAN SPECTROSCOPY

用于生物医学拉曼光谱的光纤探头

• 批准号: 7357954
• 负责人: JASON MOTZ
• 金额: $ 1.02万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357954
• 关键词: Raman spectrometry; data quality /integrity; histocompatibility typing; model; noise; performance; tissues

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In vitro experiments have demonstrated the ability of Raman spectroscopy to diagnose a wide variety of diseases. Recent in vivo investigations performed with optical fiber probes were promising but generally limited to easily accessible organs, often requiring relatively long collection times. We have implemented an optical design strategy to utilize system throughput fully by characterizing the Raman distribution from tissue. This scheme optimizes collection efficiency, minimizes noise, and has resulted in small-diameter, highly efficient Raman probes that are capable of collecting high-quality data in 1 s. Performance has been tested through simulations and experiments with tissue models and several in vitro tissue types, demonstrating that this new design can advance Raman spectroscopy as a clinically practical technique.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。体外实验已经证明了拉曼光谱诊断各种疾病的能力。最近用光纤探针进行的体内研究是有希望的，但通常限于容易接近的器官，通常需要相对较长的收集时间。我们已经实施了一种光学设计策略，充分利用系统的吞吐量，通过表征组织的拉曼分布。该方案优化了收集效率，最大限度地减少了噪声，并产生了小直径，高效的拉曼探针，能够在1秒内收集高质量的数据。性能已通过模拟和实验与组织模型和几种体外组织类型进行了测试，证明这种新的设计可以推进拉曼光谱作为一种临床实用技术。