DEVELOPMENT OF RAMAN SPECTROSCOPY FOR IN VIVO DIAGNOSIS OF ATHEROSCLEROSIS

动脉粥样硬化体内诊断拉曼光谱的发展

• 批准号: 6314194
• 负责人: JASON MOTZ
• 金额: $ 1.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314194
• 关键词: bioengineering /biomedical engineering; biomedical resource; cardiovascular system; human tissue; model design /development; technology /technique

We are developing Raman spectroscopy for in vivo diagnosis of atherosclerosis. A clinically usable diagnostic system which includes a diode laser operating at 830 nm, holographic tranmissive grating-based spectrograph with F#2 collection optics, a notch filter for rejection of Rayleigh scattered light, an AR coated deep depletion (CCD) detector for high sensitive detection has been assembled. Fiber optic probes (with integrated dielectric filters at the distal tip to reduce fluorescence/Raman background signal) to be used in catheter based in vivo studies are currently undergoing a design, refinement and testing process to allow clinically acceptable data acquisition. Once the performance of the system is evaluated clinical studies will begin at the Cleveland Clin Fdn, Cleveland, MetroWest Medical Center, Boston, and Leiden University Hospital, The Netherlands. Detailed studies of various disease states and their progression will eventually allow for optimal preventative measures and assessment of treatment protocol efficacy.

我们正在开发拉曼光谱用于体内诊断 动脉粥样硬化 一种临床上可用的诊断系统，其包括 工作波长为830 nm的二极管激光器，全息透射 基于光栅的光谱仪，具有F#2收集光学器件、陷波滤波器 为了抑制瑞利散射光， (CCD)用于高灵敏度检测的探测器已经组装好。 纤维 光学探头（在远端尖端具有集成的介电滤波器， 减少荧光/拉曼背景信号）用于导管 基于体内研究目前正在进行设计，完善， 和测试过程，以允许临床上可接受的数据采集。 一旦对系统的性能进行了评价， 开始在克利夫兰临床基金会，克利夫兰，大都会西部医疗中心， 波士顿和荷兰莱顿大学医院。 详细 对各种疾病状态及其进展的研究将 最终允许最佳的预防措施和评估 治疗方案疗效。