Effect of immunosuppression associated with point-of-lay on Salmonella infection and immunity in laying hens

产蛋点免疫抑制对蛋鸡沙门氏菌感染和免疫力的影响

• 批准号: BB/D007542/1
• 负责人: Paul Wigley
• 金额: $ 25.38万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD007542%2F1
• 关键词: Effect; immunosuppression; associated; point; lay

Salmonella enterica is one of main causes of bacterial food poisoning in the world. One type of Salmonella called Salmonella Enteritidis has the ability to infect the eggs of chickens that are infected with Salmonella bacteria. If infected eggs are eaten raw or poorly cooked, there is a chance that the person may become ill. In most cases this results in diarrheoa and a short term illness but in young children, the elderly or people with immune systems that do not work well, Salmonella infection can be very serious. In some case it may result in death. In recent years vaccination has been used as part of the control of Salmonella in chickens. However just before hens begin laying eggs (point-of-lay), their immune system becomes suppressed or less effective. This may mean that even vaccinated chickens are more likely to catch a Salmonella infection at this point. This research will find out which parts of the immune system do not work well at the point-of lay. We will then test Salmonella vaccines and measure how well they stimulate the immune system at point-of-lay and whether these vaccinated birds are more likely to get Salmonella at this time.The research will allow us to improve how and when we vaccinate chickens against Salmonella so they are protected when they start to lay eggs. It will also help us make better vaccines that protect chickens better and for longer than current vaccines.

肠道沙门氏菌是世界范围内引起细菌性食物中毒的主要原因之一。一种称为沙门氏菌的沙门氏菌能够感染感染沙门氏菌细菌感染的鸡蛋。如果受感染的鸡蛋生吃或煮得不好，这个人就有可能生病。在大多数情况下，这会导致腹泻和短期疾病，但在幼儿，老年人或免疫系统不正常的人中，沙门氏菌感染可能非常严重。在某些情况下，它可能导致死亡。近年来，疫苗接种已被用作鸡沙门氏菌控制的一部分。然而，就在母鸡开始下蛋之前（产蛋点），它们的免疫系统变得受到抑制或效率降低。这可能意味着即使是接种疫苗的鸡也更有可能在这一点上感染沙门氏菌。这项研究将找出免疫系统的哪些部分在性交时不起作用。然后我们将测试沙门氏菌疫苗，并测量它们在产蛋时对免疫系统的刺激程度，以及这些接种疫苗的鸡是否更有可能在这个时候感染沙门氏菌。这项研究将使我们能够改进如何以及何时接种沙门氏菌疫苗，以便在它们开始产卵时得到保护。它还将帮助我们制造更好的疫苗，比现有疫苗更好、更长时间地保护鸡。

项目成果

Salmonella enterica in the Chicken: How it has Helped Our Understanding of Immunology in a Non-Biomedical Model Species.

• DOI: 10.3389/fimmu.2014.00482
• 发表时间: 2014
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Wigley P

Immunological changes at point-of-lay increase susceptibility to Salmonella enterica Serovar enteritidis infection in vaccinated chickens.

• DOI: 10.1371/journal.pone.0048195
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Johnston CE;Hartley C;Salisbury AM;Wigley P
• 通讯作者: Wigley P

Immunity to bacterial infection in the chicken.

• DOI: 10.1016/j.dci.2013.04.008
• 发表时间: 2013-11
• 期刊: Developmental and comparative immunology
• 影响因子: 2.9
• 作者: P. Wigley

Cellular and functional changes in the reproductive tract associated with onset-of-lay in chickens

与鸡产蛋开始相关的生殖道细胞和功能变化

• DOI: 10.1016/j.vetimm.2008.10.071
• 发表时间: 2009
• 期刊: Veterinary Immunology and Immunopathology
• 影响因子: 1.8
• 作者: Johnston C