RELAXATION STUDIES ON ENZYME FLEXIBILITY

酶灵活性的松弛研究

• 批准号: 7420580
• 负责人: GEORGE NEAL PHILLIPS
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-20 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420580
• 关键词: enzymes; relaxation; temperature

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We intend to study relaxation processes in small monomeric enzymes as a function of temperature to test whether catalytic activity and molecular motions can be correlated. Initially HSQC data will be collected to verify the assignability of spectra, followed by relaxation studies.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们打算研究小型单体酶中的松弛过程，以测试催化活性和分子运动是否可以相关。最初将收集HSQC数据以验证光谱的分配性，然后进行放松研究。