STRUCTURE & MECHANISM OF HYDROLYTIC ANTIBODIES

结构

• 批准号: 6281182
• 负责人: THOMAS Sterling SCANLAN
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281182
• 关键词: biological products; biomaterials; biomedical resource; biotechnology; spectrometry; structural biology

We are studying the structure and mechanisms of a unique family of catalytic antibodies in an effort to establish rules that will permit more active catalytic antibodies to be generated. Using a variety of chemical, biochemical and molecular biology techniques, we are engineering improvements into our catalytic antibodies in a structure-guided way. Our goal is to monitor the structure-function relationships involved in engineering these catalytic improvements.

我们正在研究一个独特的家庭的结构和机制， 催化抗体，以建立规则， 产生更有活性的催化抗体。 使用各种 化学、生物化学和分子生物学技术， 在我们的催化抗体中进行工程改进， 结构导向方式。 我们的目标是监测结构-功能 在设计这些催化性改进中所涉及的关系。