ROTAVIRUS

轮状病毒

• 批准号: 7357774
• 负责人: Bidadi Venkataram Prasad
• 金额: $ 1.51万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357774
• 关键词: ROTAVIRUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rotavirus is a major pathogen of infantile gastroenteritis. It is an icosahedral virus, 1000 ¿ in diameter, with a complex architecture consisting of three concentric capsid layers enclosing 11 dsRNA segments. Over several years we have been trying to determine the structure of various forms of this medically important virus. We are presently using the NCMI facility to carry out high-resolution structural analysis of transcriptionally competent, transcriptionally incompetent and transcriptionally active forms of rotavirus particles, to understand molecular mechanisms underlying the fascinating process of endogenous transcription in these viruses. In addition, we also study various molecular components of rotavirus.

该主题项目是利用NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是针对该中心的，这不是调查人员的机构。轮状病毒是基础设施胃炎的主要病原体。它是一种直径为1000€的二十面体病毒，其复杂的结构由包含11个dsRNA段的三个浓度的衣壳层组成。在几年中，我们一直试图确定这种医学重要的病毒的各种形式的结构。目前，我们正在使用NCMI设施对轮廓能力，转录无能力和转录活性形式进行轮廓病毒颗粒的高分辨率结构分析，以了解这些病毒中内源性转录过程迷人过程的分子机制。此外，我们还研究轮状病毒的各种分子成分。