SAN1 INTERACTIONS

SAN1 交互

• 批准号: 7420804
• 负责人: Richard George Gardner
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420804
• 关键词: fungal proteins; protein degradation; proteins; ubiquitin; ubiquitin protein ligase; yeasts

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The yeast protein San1 is a ubiquitin-protein ligase that functions in the ubiquitin-mediated proteasomal degradation of aberrant proteins in the nucleus. It is not clear if San1 functions alone, or has cognate interacting partners vital to its function. We will search for San1-interacting proteins using the yeast 2-hybrid method.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。酵母蛋白San 1是一种泛素-蛋白质连接酶，其在泛素介导的细胞核异常蛋白质的蛋白酶体降解中发挥作用。尚不清楚San 1是否单独发挥作用，或者是否有对其功能至关重要的同源相互作用伙伴。我们将使用酵母双杂交方法寻找与San 1相互作用的蛋白。