FAST 3D PEDIATRIC BRAIN MRSI

快速 3D 儿科脑部 MRSI

• 批准号: 7358772
• 负责人: DONGHYUN KIM
• 金额: $ 0.62万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358772
• 关键词: FAST; 3D; PEDIATRIC; BRAIN; MRSI

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Pediatric neurospectroscopy provides unique information regarding the metabolic variations during normal and abnormal brain development. Spectroscopic imaging can add to this feature by providing topologic information, but rapid scan times are needed for clinical feasible protocols. We have thus developed a 6 min 3D MRSI clinical protocol to study. The clinical goal is to understand the metabolic differences in subjects with motor dysfunction by analyzing metabolite levels in the corticospinal tract (CST). Methods and Discussion: A 3D MRSI sequence was developed using PRESS excitation in combination with a spiral based readout gradient for use at 3T. A dualband spectral spatial spin echo pulse for 3T neuro applications, designed to excite only 1% of the water signal and suppress lipids while passing the NAA, Cr, and Cho resonances was used. Data collection using a 8 channel receiver coil provided increased signal to noise ratio (SNR). Overall, the following MRSI parameters were used for data collection; 3T, TR/TE = 1500/130 ms, 32x32x8 matrix, 1cc spatial resolution, 6:24 min scan time. Quantification was performed by measuring voxels corresponding to the CST and incoporating this into the LCModel fitting procedure. In vivo studies demonstrated excellent results with SNRs exceeding that from adults. Metabolite values were recorded from the CST beginning at the precentral gyrus lateral to the centrum semiovale and ending at the cerebral peduncle region. NAA/Cho showed a linear trend in the change of metabolite ratios for the CST given this age range. Further data collection is needed to confirm this trend. Regardless, the ability to analyze spectra from the whole CST pathway (and other pathways) is unique using spectroscopic imaging. Acknowledgements: NIH RR 09784, NS40117, NS46432, RR01271

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。简介：小儿神经光谱学提供了关于正常和异常大脑发育期间代谢变化的独特信息。光谱成像可以通过提供拓扑信息来增加这一特征，但是对于临床可行的方案，需要快速扫描时间。因此，我们开发了一个6分钟的3D MRSI临床方案进行研究。临床目标是通过分析皮质脊髓束（CST）中的代谢物水平来了解运动功能障碍受试者的代谢差异。方法和讨论：使用PRESS激发结合基于螺旋的读出梯度开发了3D MRSI序列，以在3 T下使用。使用了用于3 T神经元应用的双波段光谱空间自旋回波脉冲，其设计为仅激发1%的水信号并抑制脂质，同时通过NAA、Cr和Cho共振。使用8通道接收器线圈的数据收集提供了增加的信噪比（SNR）。总体而言，以下MRSI参数用于数据收集; 3 T，TR/TE = 1500/130 ms，32 x32 x8矩阵，1cc空间分辨率，6：24 min扫描时间。通过测量对应于CST的体素并将其整合到LC模型拟合程序中来进行定量。 体内研究显示了优异的结果，SNR超过成人。从CST开始记录代谢物值，开始于半卵圆中心外侧的中央前回，结束于大脑脚区域。NAA/Cho在此年龄范围内CST的代谢物比例变化呈线性趋势。需要进一步收集数据以确认这一趋势。无论如何，使用光谱成像分析来自整个CST途径（和其他途径）的光谱的能力是独特的。 鸣谢：NIH RR 09784、NS 40117、NS 46432、RR 01271