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Nutritional sensitivity of periparturient immune responses to parasites in mammals

哺乳动物围产期免疫反应对寄生虫的营养敏感性

基本信息

批准号：
BB/D017890/1
负责人：
Jos Houdijk
金额：
$ 38.46万
依托单位：
Scotland's Rural College
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FD017890%2F1
关键词：
Nutritional sensitivity periparturient immune responses

项目摘要

Because animals, including humans, are often exposed to parasites, they will eventually become resistant to them, i.e. they will develop an effective immunity. However, there are times in the life of animals that this immunity to parasites does not operate effectively. One such time is around giving birth, i.e. during late pregnancy and subsequent lactation, when immunity to parasites often breaks down. This is referred to as the periparturient relaxation of immunity (PPRI). The importance of PPRI has long been known, but why it occurs and how it can be manipulated is still poorly understood. Recent investigations in lactating rats, infected with the gut worm Nippostrongylus brasiliensis, have shown that poor protein nutrition increases worm numbers, which is indicative of increased PPRI. In this proposal, we aim to investigate how rat protein nutrition influences immune responses that are involved in PPRI. We will first test the effects of low vs high levels of protein nutrition on immune responses to N. brasiliensis during lactation at various time points. We need to do this because effects of nutrition on immunity may differ over time, and we need to ensure that for the rest of the proposal we take our measurements at the most appropriate time point. We will then test the effects of six different levels of protein (from low to high) in order to see how protein nutrition affects the immune responses at this time point. Effects of protein nutrition are by definition effects of its building blocks, the amino acids. There are about 20 amino acids, and some are called essential amino acids because they can not be synthesised in the body. Essential amino acids have to be provided by food, and we will focus our investigations on two essential amino acids that are found in high concentrations in the proteins that are associated with immunity to parasites, and on four amino acids that are known to influence immunity in general. The effects of these amino acids on the extent of PPRI will be investigated. Lastly, we will investigate how fast improved protein nutrition can restore immunity. The information derived from these experiments will help to increase our knowledge on how nutrition can affect immunity to parasites, which will be useful to control parasites with minimal use of drugs.

由于动物，包括人类，经常接触寄生虫，它们最终会对寄生虫产生抵抗力，即它们会产生有效的免疫力。然而，在动物的一生中，这种对寄生虫的免疫力有时不能有效地发挥作用。一个这样的时间是在分娩前后，即在怀孕后期和随后的哺乳期，此时对寄生虫的免疫力通常会下降。这被称为围产期免疫松弛（PPRI）。PPRI的重要性早已为人所知，但人们对它发生的原因以及如何操纵它仍然知之甚少。最近对感染肠道蠕虫巴西日本圆线虫的哺乳期大鼠的研究表明，蛋白质营养不良会增加蠕虫数量，这表明PPRI增加。在这项提案中，我们的目标是研究大鼠蛋白质营养如何影响参与PPRI的免疫反应。我们将首先测试低水平和高水平蛋白质营养对免疫反应的影响。巴西在哺乳期间在不同的时间点。我们需要这样做，因为营养对免疫力的影响可能会随着时间的推移而有所不同，我们需要确保在提案的其余部分，我们在最合适的时间点进行测量。然后，我们将测试六种不同水平的蛋白质（从低到高）的影响，以了解蛋白质营养如何影响此时的免疫反应。蛋白质营养的影响是由其结构单元氨基酸的影响定义的。大约有20种氨基酸，其中一些被称为必需氨基酸，因为它们不能在体内合成。必需氨基酸必须由食物提供，我们将集中研究在与寄生虫免疫相关的蛋白质中发现的两种高浓度必需氨基酸，以及已知影响免疫力的四种氨基酸。将研究这些氨基酸对PPRI程度的影响。最后，我们将研究如何快速改善蛋白质营养可以恢复免疫力。从这些实验中获得的信息将有助于增加我们对营养如何影响对寄生虫的免疫力的知识，这将有助于以最少的药物控制寄生虫。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Amelioration of the periparturient relaxation of immunity to parasites through a reduction in mammalian reproductive effort.

通过减少哺乳动物的繁殖努力来改善围产期对寄生虫的免疫力松弛。

DOI：
10.1016/j.ijpara.2012.09.010
发表时间：
2012
期刊：
International journal for parasitology
影响因子：
4
作者：
Jones LA
通讯作者：
Jones LA

Genome-wide transcriptomic analysis of intestinal tissue to assess the impact of nutrition and a secondary nematode challenge in lactating rats.

DOI：
10.1371/journal.pone.0020771
发表时间：
2011
期刊：
PloS one
影响因子：
3.7
作者：
Athanasiadou S;Jones LA;Burgess ST;Kyriazakis I;Pemberton AD;Houdijk JG;Huntley JF
通讯作者：
Huntley JF

Dietary protein and energy supplies differentially affect resistance to parasites in lactating mammals.

膳食蛋白质和能量供应对哺乳期哺乳动物对寄生虫的抵抗力有不同的影响。