XAS STUDIES OF INTERMEDIATES IN REACTIONS OF CU(I) AND O2

CU(I)和O2反应中间体的XAS研究

• 批准号: 7370413
• 负责人: KEITH O HODGSON
• 金额: $ 0.24万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7370413
• 关键词: XAS; STUDIES; INTERMEDIATES; REACTIONS; CU

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A variety of enzymes use copper to activate O2 and to mediate a range of O2 reactivities. Small synthetic molecules offer a means of probing fundamental issues of Cu/O2 chemistry, in a detailed and systematic way. XAS at the Cu K-edge has proven to be an increasingly powerful technique in Cu/O2 chemistry, for its ability to probe such important variables as Cu oxidation state, Cu-Cu distance, as well as Cu coordination geometry, in the solid or solution state. We propose a series of experiments directed at understanding such basic issues as the nuclearity of Cu : O2 reactivity under different conditions, ligand effects on the structure of the Cu/O2 species which form, and structure-reactivity correlations in these species. Because these small molecules serve as enzyme active site models, work proposed in this study addresses bioinorganic activation of O2 by copper as well as several more fundamental issues in metal/O2 chemistry.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。多种酶使用铜来激活O2并介导一系列O2反应性。小的合成分子提供了一种详细和系统地探索Cu/O2化学基本问题的方法。XAS在Cu K-边缘已被证明是一个越来越强大的技术在Cu/O2化学，其探测能力，如Cu的氧化态，Cu-Cu距离，以及Cu的配位几何形状，在固体或溶液状态等重要变量。我们提出了一系列的实验，旨在了解这些基本问题的Cu：O2反应性的核在不同条件下，配体的Cu/O2物种的结构上的影响，形成，和这些物种的结构反应性的相关性。由于这些小分子作为酶活性位点模型，在这项研究中提出的工作解决了生物无机激活O2铜以及金属/O2化学中的几个更基本的问题。