COCRYSTALLIZATION STUDIES OF MEDICALLY RELEVANT PROTEINS WITH SMALL MOLECULE INH

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。我们将检查两个不同的治疗目标。第一个是与Amgen配体络合的P38。P38与炎症有关，因此这些分子是潜在的抗炎药。第二个蛋白质-配体复合体将是KDR。KDR参与了血管生成的调节，因此这些化合物是潜在的抗癌药物。我预计这些晶体的衍射率将达到2.3埃甚至更高。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will be examining two different therapeutic targets. The first is P38 complexed to Amgen ligands. P38 is involved in inflammation so these molecules are potential anti-inflammatory agents. The second protein-ligand complexes will be KDR. KDR is involved in the regulation of angiogenesis so these compounds are potential anti-cancer agents. I expect these crystals to diffract to 2.3 Angstroms and beyond.