COCRYSTALLIZATION STUDIES OF MEDICALLY RELEVANT PROTEINS WITH SMALL MOLECULE INH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们将研究两种不同的治疗靶点。 第一种是与安进配体复合的人11 β HSD-1。 HSD-1代表羟基类固醇脱氢酶1，参与调节脂肪组织中的皮质醇水平，可能是脂肪代谢的重要调节剂。 第二种蛋白质-配体复合物将是MK2。 MK2参与炎症的调节。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will be examining two different therapeutic targets. The first is human 11 beta HSD-1 complexed to Amgen ligands. HSD-1 stands for hydroxy steroid dehygrogenase 1 and is involved in the regulation of cortisol levels in fat tissues and may be an important regulator of fat metabolism. The second protein-ligand complexes will be MK2. MK2 is involved in the regulation of inflammation.