PATHOGENESIS OF NON-INSULIN DEPENDENT DIABETES MELLITUS

非胰岛素依赖型糖尿病的发病机制

• 批准号: 7368186
• 负责人: Thomas A Buchanan
• 金额: $ 6.31万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368186
• 关键词: PATHOGENESIS; NON; INSULIN; DEPENDENT; DIABETES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an ongoing observational study designed to identify potential causes of type 2 diabetes mellitus at the physiological level in relatively young, high-risk Hispanic women. Subjects have been scheduled for detailed metabolic characterization at 12-15-month intervals after an index pregnancy complicated by gestational diabetes mellitus. Follow-up continues until they develop hyperglycemia requiring clinical intervention. Data are analyzed to: (a) define patterns of change in glucose levels across a ~10-year period of time and a wide range of changing ?-cell function; (b) identify predictors and potential determinants of falling ?-cell function during long-term follow-up; and (c) explore the potential role of adipokines in the generation of insulin resistance, ?-cell dysfunction and diabetes.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项正在进行的观察性研究，旨在确定相对年轻，高风险西班牙裔女性在生理水平上2型糖尿病的潜在原因。受试者在首次妊娠合并妊娠期糖尿病后，每隔12-15个月进行一次详细的代谢表征。继续随访，直到他们出现需要临床干预的高血糖症。分析数据的目的是：（a）定义约10年时间内葡萄糖水平的变化模式和广泛的变化范围。细胞功能;（B）确定跌倒的预测因素和潜在决定因素？长期随访期间的细胞功能;（c）探索脂肪因子在胰岛素抵抗产生中的潜在作用，细胞功能障碍和糖尿病。