PATHOGENESIS OF NON-INSULIN DEPENDENT DIABETES MELLITUS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an ongoing observational study designed to identify potential causes of type 2 diabetes mellitus at the physiological level in relatively young, high-risk Hispanic women. Subjects have been scheduled for detailed metabolic characterization at 12-15-month intervals after an index pregnancy complicated by gestational diabetes mellitus. Follow-up continues until they develop hyperglycemia requiring clinical intervention. Data are analyzed to: (a) define patterns of change in glucose levels across a ~10-year period of time and a wide range of changing ?-cell function; (b) identify predictors and potential determinants of falling ?-cell function during long-term follow-up; and (c) explore the potential role of adipokines in the generation of insulin resistance, ?-cell dysfunction and diabetes.