Southern California Clinical and Translational Science Institute

联系PD/PI：Buchanan，Thomas A 整体组件 项目摘要/摘要 南加州临床与翻译科学研究所(SC CTSI)正在为 第三轮临床和转化科学奖(CTSA)资助在一个戏剧性增长和 机会在我们的枢纽。SCCTSI包括南加州大学(USC)和儿童 洛杉矶医院(CHLA)与洛杉矶县卫生局密切合作 服务。我们的愿景是成为临床和翻译研究的领导者，使不同的社区和 特殊人群。我们的方法建立在过去成功的基础上，承认临床环境的变化 和翻译研究(CTR)、CTSA计划的优先事项以及我们的 研究人员、学员、患者和社区。我们的业务范围利用了临床、卫生系统和 社区研究、教育和培训，主要有两个主题：多样性和影响力。多样性是 反映在我们从事的社区、卫生系统和科学学科中，以改善卫生保健和 结果。影响包括学术生产力以及对我们的劳动力、卫生系统、 病人和社区。为了在我们的范围和主题范围内实现我们的愿景，我们提出了六项建议 具体目标：(1)劳动力发展：培养一支具有知识、技能和技能的高技能劳动力队伍 对开展严谨和可重复的研究的态度侧重于不同人群不断发展的健康需求 社区。(2)协作和参与：创造一种基于团队的研究、参与所有人的文化 利益相关者并遵循团队科学的合理原则，是解决复杂问题的标准方法 在健康和研究方面的挑战。(3)整合：让我们的不同社区参与建立临床 研究优先事项；确定研究障碍；开发、示范和传播创新 确保跨社区和寿命的完全合作的临床研究的方法。(4)方法和 过程：将质量和过程改进的原则应用于临床和转化性研究，以开发 并分享提高效率、质量和影响的新方法。(5)信息学：提供敏捷 包含研究、临床护理、社区及其环境的信息生态系统，提供 健康和疾病的整体观，是发现、创新和洞察的引擎。(6)CTSA HUB：参与CTSA网络活动，进行多站点研究，采用同行的成功模式， 并开发、示范和传播创新方法。实现这些目标将推动 CTR的纪律旨在改善不同和服务不足的社区的健康。

Contact PD/PI: Buchanan, Thomas A OVERALL COMPONENT Project Summary/Abstract The Southern California Clinical and Translational Science Institute (SC CTSI) is submitting this revision for a third cycle of Clinical and Translational Science Award (CTSA) funding at a time of dramatic growth and opportunity at our hub. The SC CTSI encompasses the University of Southern California (USC) and Children's Hospital of Los Angeles (CHLA), in close partnership with the Los Angeles County Department of Health Services. Our vision is to be a leader in clinical and translational research to benefit diverse communities and special populations. Our approach builds on past success, acknowledging the changing landscape of clinical and translational research (CTR), the priorities of the CTSA program, and the evolving needs of our researchers, trainees, patients and communities. Our scope leverages strengths in clinical, health system, and community research, education and training, within two overarching themes: diversity and impact. Diversity is reflected in the communities, health systems, and scientific disciplines we engage to improve health care and outcomes. Impact encompasses academic productivity as well as benefit to our workforce, health systems, patients, and communities. To pursue our vision in the context of our scope and themes, we propose six specific aims: (1) Workforce Development: Train a highly skilled workforce with the knowledge, skills, and attitudes to conduct rigorous and reproducible research focused on the evolving health needs of diverse communities. (2) Collaboration and Engagement: Create a culture in which team-based research, engaging all stakeholders and following sound principles of team science, is the standard approach to addressing complex challenges in health and research. (3) Integration: Engage our diverse communities to establish clinical research priorities; identify barriers to research; and develop, demonstrate and disseminate innovative approaches to assure fully partnered clinical research across communities and the lifespan. (4) Methods and Process: Apply principles of quality and process improvement to clinical and translational research to develop and share novel approaches to enhance efficiency, quality and impact. (5) Informatics: Provide an agile information ecosystem that encompasses research, clinical care, communities and their environment, providing a holistic view of health and disease and serving as the engine for discovery, innovation and insight. (6) CTSA Hub: Participate in CTSA network activities, conduct multi-site studies, adopt successful models from peers, and develop, demonstrate and disseminate innovative approaches. Achieving these aims will advance the discipline of CTR directed at improving health in diverse and underserved communities.