Southern California Clinical and Translational Science Institute

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Contact PD/PI: Buchanan, Thomas A OVERALL COMPONENT Project Summary/Abstract The Southern California Clinical and Translational Science Institute (SC CTSI) is submitting this revision for a third cycle of Clinical and Translational Science Award (CTSA) funding at a time of dramatic growth and opportunity at our hub. The SC CTSI encompasses the University of Southern California (USC) and Children's Hospital of Los Angeles (CHLA), in close partnership with the Los Angeles County Department of Health Services. Our vision is to be a leader in clinical and translational research to benefit diverse communities and special populations. Our approach builds on past success, acknowledging the changing landscape of clinical and translational research (CTR), the priorities of the CTSA program, and the evolving needs of our researchers, trainees, patients and communities. Our scope leverages strengths in clinical, health system, and community research, education and training, within two overarching themes: diversity and impact. Diversity is reflected in the communities, health systems, and scientific disciplines we engage to improve health care and outcomes. Impact encompasses academic productivity as well as benefit to our workforce, health systems, patients, and communities. To pursue our vision in the context of our scope and themes, we propose six specific aims: (1) Workforce Development: Train a highly skilled workforce with the knowledge, skills, and attitudes to conduct rigorous and reproducible research focused on the evolving health needs of diverse communities. (2) Collaboration and Engagement: Create a culture in which team-based research, engaging all stakeholders and following sound principles of team science, is the standard approach to addressing complex challenges in health and research. (3) Integration: Engage our diverse communities to establish clinical research priorities; identify barriers to research; and develop, demonstrate and disseminate innovative approaches to assure fully partnered clinical research across communities and the lifespan. (4) Methods and Process: Apply principles of quality and process improvement to clinical and translational research to develop and share novel approaches to enhance efficiency, quality and impact. (5) Informatics: Provide an agile information ecosystem that encompasses research, clinical care, communities and their environment, providing a holistic view of health and disease and serving as the engine for discovery, innovation and insight. (6) CTSA Hub: Participate in CTSA network activities, conduct multi-site studies, adopt successful models from peers, and develop, demonstrate and disseminate innovative approaches. Achieving these aims will advance the discipline of CTR directed at improving health in diverse and underserved communities. Glossary ACT – CTSA Program Accrual to Clinical Trials Network IRB – Institutional Review Board BERD – Biostatistics, Epidemiology, Research Design core group ISI – USC Information Sciences Institute CD2H – CTSA Program National Center for Data to Health IT – Information Technology CE – Community Engagement core group KSOM – Keck School of Medicine of USC CEREC – CTSA External Reviewer Exchange Consortium LA – Los Angeles CHDP – Community Health Demonstration Projects LAC DHS – LA County Department of Health Services CHLA – Children's Hospital Los Angeles LGBTQ+ – Lesbian, Gay, Bisexual, Transgender, Questioning CLIC – CTSA Center for Leading Innovation and Collaboration MRC – Mentor Resource Center CLS – Community Listening Session N3C – National COVID Cohort Collaborative CRI – Clinical Research Informatics core group NGHP – Nickerson Gardens Housing Project CSU – Colorado State University NIH – National Institutes of Health CSULA – California State University Los Angeles NLP – Natural Language Processing CTR – Clinical and Translational Research OC/OH-LA – Our Community/Our Health Los Angeles CTTI – Clinical Trials Transformation Initiative PBRN – Practice-Based Research Network DIAMOND – Development, Implementation, and Assessment of Novel Training in Domain-based Competencies Portal QbD – Quality by Design EAC – External Advisory Committee SC CTSI – Southern California Clinical and Translational Science Institute EDWAP – Enterprise Data Warehouse and Analytics Platform SEDoH – Social and Environmental Determinants of Health EHR – Electronic Health Record SNA – Social Network Analysis ERC – Education Resource Center SSI – USC Spatial Sciences Institute FHIR – Fast Healthcare Interoperability Resources STELLAR – Self Career Training Education Lifelong Learning Advancement Resource, a collaboration with Georgia CTSA HACLA – Housing Authority of the City of Los Angeles TBV – Team Building Voucher HDS – Healthcare Delivery Science TIN – Trial Innovation Network HHS – Hollywood, Health & Society TS – Team Science I2b2 – Informatics for Integrating Biology & the Bedside UCLA – University of California Los Angeles ICD – Institutional Career Development URM – Under-Represented in Medicine IIT – Investigator-Initiated Trial USC – University of Southern California IOB – Internal Oversight Board WD – Workforce Development core group Project Summary/Abstract Page 207 Contact PD/PI: Buchanan, Thomas A UL1