Southern California Clinical and Translational Science Institute

南加州临床与转化科学研究所

• 批准号: 10559463
• 负责人: Thomas A Buchanan
• 金额: $ 900.97万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559463
• 关键词: Address; Adopted; Advisory Committees; African American; Area; Artificial Intelligence; Asian Americans; Attitude; Biology; Biometry; California; Child Health Services; Cities; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Colorado; Communities; Community Health; Community Health Aides; Community Health Systems; Competence; Complement; Complex; County; Data; Data Analytics; Development; Development Plans; Discipline; Disease; Ecosystem; Electronic Health Record; Environment; Fast Healthcare Interoperability Resources; Fostering; Funding; Gardenal; Glossary; Goals; Growth; Health; Health Services; Health system; Housing; Improve Access; Individual; Informatics; Information Sciences; Information Technology; Institutes; Institution; Institutional Review Boards; Instruction; Knowledge; Latino; Leadership; Lesbian Gay Bisexual Transgender; Lesbian Gay Bisexual Transgender Queer; Longevity; Los Angeles; Machine Learning; Medicine; Mentors; Methods; Mission; Modeling; Natural Language Processing; Pathway Analysis; Patients; Pediatric Hospitals; Peer Review; Plant Roots; Population; Population Heterogeneity; Population Research; Process; Productivity; Program Sustainability; Reproducibility; Request for Applications; Research; Research Design; Research Institute; Research Personnel; Research Priority; Research Training; Resources; Role; Science; Services; Site; Social Network; Social Sciences; Societies; Special Population; Subgroup; Talents; Television; Time; Training; Training and Education; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Vision; Work; Workforce Development; authority; base; care outcomes; career; career development; clinical care; cohort; community based participatory research; community engaged research; community engagement; coronavirus disease; data hub; data infrastructure; data warehouse; design; education resources; epidemiology study; experience; health care delivery; health data; health organization; improved; innovation; insight; investigator-initiated trial; life-long learning; medical schools; member; multidisciplinary; novel; novel strategies; peer; personalized approach; practice-based research network; programs; research and development; skills; social; sound; success; systems research; tool; underserved community; voucher

Contact PD/PI: Buchanan, Thomas A OVERALL COMPONENT Project Summary/Abstract The Southern California Clinical and Translational Science Institute (SC CTSI) is submitting this revision for a third cycle of Clinical and Translational Science Award (CTSA) funding at a time of dramatic growth and opportunity at our hub. The SC CTSI encompasses the University of Southern California (USC) and Children's Hospital of Los Angeles (CHLA), in close partnership with the Los Angeles County Department of Health Services. Our vision is to be a leader in clinical and translational research to benefit diverse communities and special populations. Our approach builds on past success, acknowledging the changing landscape of clinical and translational research (CTR), the priorities of the CTSA program, and the evolving needs of our researchers, trainees, patients and communities. Our scope leverages strengths in clinical, health system, and community research, education and training, within two overarching themes: diversity and impact. Diversity is reflected in the communities, health systems, and scientific disciplines we engage to improve health care and outcomes. Impact encompasses academic productivity as well as benefit to our workforce, health systems, patients, and communities. To pursue our vision in the context of our scope and themes, we propose six specific aims: (1) Workforce Development: Train a highly skilled workforce with the knowledge, skills, and attitudes to conduct rigorous and reproducible research focused on the evolving health needs of diverse communities. (2) Collaboration and Engagement: Create a culture in which team-based research, engaging all stakeholders and following sound principles of team science, is the standard approach to addressing complex challenges in health and research. (3) Integration: Engage our diverse communities to establish clinical research priorities; identify barriers to research; and develop, demonstrate and disseminate innovative approaches to assure fully partnered clinical research across communities and the lifespan. (4) Methods and Process: Apply principles of quality and process improvement to clinical and translational research to develop and share novel approaches to enhance efficiency, quality and impact. (5) Informatics: Provide an agile information ecosystem that encompasses research, clinical care, communities and their environment, providing a holistic view of health and disease and serving as the engine for discovery, innovation and insight. (6) CTSA Hub: Participate in CTSA network activities, conduct multi-site studies, adopt successful models from peers, and develop, demonstrate and disseminate innovative approaches. Achieving these aims will advance the discipline of CTR directed at improving health in diverse and underserved communities. Glossary ACT – CTSA Program Accrual to Clinical Trials Network IRB – Institutional Review Board BERD – Biostatistics, Epidemiology, Research Design core group ISI – USC Information Sciences Institute CD2H – CTSA Program National Center for Data to Health IT – Information Technology CE – Community Engagement core group KSOM – Keck School of Medicine of USC CEREC – CTSA External Reviewer Exchange Consortium LA – Los Angeles CHDP – Community Health Demonstration Projects LAC DHS – LA County Department of Health Services CHLA – Children's Hospital Los Angeles LGBTQ+ – Lesbian, Gay, Bisexual, Transgender, Questioning CLIC – CTSA Center for Leading Innovation and Collaboration MRC – Mentor Resource Center CLS – Community Listening Session N3C – National COVID Cohort Collaborative CRI – Clinical Research Informatics core group NGHP – Nickerson Gardens Housing Project CSU – Colorado State University NIH – National Institutes of Health CSULA – California State University Los Angeles NLP – Natural Language Processing CTR – Clinical and Translational Research OC/OH-LA – Our Community/Our Health Los Angeles CTTI – Clinical Trials Transformation Initiative PBRN – Practice-Based Research Network DIAMOND – Development, Implementation, and Assessment of Novel Training in Domain-based Competencies Portal QbD – Quality by Design EAC – External Advisory Committee SC CTSI – Southern California Clinical and Translational Science Institute EDWAP – Enterprise Data Warehouse and Analytics Platform SEDoH – Social and Environmental Determinants of Health EHR – Electronic Health Record SNA – Social Network Analysis ERC – Education Resource Center SSI – USC Spatial Sciences Institute FHIR – Fast Healthcare Interoperability Resources STELLAR – Self Career Training Education Lifelong Learning Advancement Resource, a collaboration with Georgia CTSA HACLA – Housing Authority of the City of Los Angeles TBV – Team Building Voucher HDS – Healthcare Delivery Science TIN – Trial Innovation Network HHS – Hollywood, Health & Society TS – Team Science I2b2 – Informatics for Integrating Biology & the Bedside UCLA – University of California Los Angeles ICD – Institutional Career Development URM – Under-Represented in Medicine IIT – Investigator-Initiated Trial USC – University of Southern California IOB – Internal Oversight Board WD – Workforce Development core group Project Summary/Abstract Page 207 Contact PD/PI: Buchanan, Thomas A UL1

联系PD/PI：Buchanan，Thomas A 整体组件 项目摘要/摘要 南加州临床与翻译科学研究所(SC CTSI)正在为 第三轮临床和转化科学奖(CTSA)资助在一个戏剧性增长和 机会在我们的枢纽。SCCTSI包括南加州大学(USC)和儿童 洛杉矶医院(CHLA)与洛杉矶县卫生局密切合作 服务。我们的愿景是成为临床和翻译研究的领导者，使不同的社区和 特殊人群。我们的方法建立在过去成功的基础上，承认临床环境的变化 和翻译研究(CTR)、CTSA计划的优先事项以及我们的 研究人员、学员、患者和社区。我们的业务范围利用了临床、卫生系统和 社区研究、教育和培训，主要有两个主题：多样性和影响力。多样性是 反映在我们从事的社区、卫生系统和科学学科中，以改善卫生保健和 结果。影响包括学术生产力以及对我们的劳动力、卫生系统、 病人和社区。为了在我们的范围和主题范围内实现我们的愿景，我们提出了六项建议 具体目标：(1)劳动力发展：培养一支具有知识、技能和技能的高技能劳动力队伍 对开展严谨和可重复的研究的态度侧重于不同人群不断发展的健康需求 社区。(2)协作和参与：创造一种基于团队的研究、参与所有人的文化 利益相关者并遵循团队科学的合理原则，是解决复杂问题的标准方法 在健康和研究方面的挑战。(3)整合：让我们的不同社区参与建立临床 研究优先事项；确定研究障碍；开发、示范和传播创新 确保跨社区和寿命的完全合作的临床研究的方法。(4)方法和 过程：将质量和过程改进的原则应用于临床和转化性研究，以开发 并分享提高效率、质量和影响的新方法。(5)信息学：提供敏捷 包含研究、临床护理、社区及其环境的信息生态系统，提供 健康和疾病的整体观，是发现、创新和洞察的引擎。(6)CTSA HUB：参与CTSA网络活动，进行多站点研究，采用同行的成功模式， 并开发、示范和传播创新方法。实现这些目标将推动 CTR的纪律旨在改善不同和服务不足的社区的健康。 词汇表 ACT-CTSA计划适用于临床试验网络IRB-机构审查委员会 生物统计学、流行病学、研究设计核心小组ISI-南加州大学信息科学研究所 CD2H-CTSA计划国家数据到健康IT-信息技术中心 CE-社区参与核心小组南加州大学KSOM-Keck医学院 CEREC-CTSA外部审稿人交流联盟洛杉矶-洛杉矶 社区卫生示范项目LAC DHS-LA县卫生服务局 CHLA-洛杉矶儿童医院LGBTQ+-女同性恋者、男同性恋者、双性恋者、变性人、询问 CLIC-CTSA领先创新与协作中心MRC-导师资源中心 CLS-社区聆听会议N3C-国家COVID队列协作 CRI-临床研究信息学核心小组NGHP-尼克森花园住房项目 CSU-科罗拉多州立大学NIH-国立卫生研究院 CSULA-加州州立大学洛杉矶自然语言处理 CTR-临床和翻译研究OC/OH-LA-我们的社区/我们的健康洛杉矶 CTTI-临床试验转化计划PBRN-以实践为基础的研究网络 钻石-开发、实施和评估 基于领域的能力门户QbD-Quality by Design的新培训 选管会--外部咨询委员会 SC CTSI-南加州临床和翻译 理工学院 EDWAP-企业数据仓库和分析平台SEDoH-健康的社会和环境决定因素 EHR-电子健康记录SNA-社交网络分析 教育资源中心SSI-南加州大学空间科学研究所 FHIR-快速医疗互操作性资源 星自我职业培训教育终身学习 与佐治亚州CTSA合作的高级资源 HACLA-洛杉矶市住房管理局TBV-团队建设代金券 HDS-医疗提供科学TIN-试验创新网络 HHS-好莱坞、健康和社会TS-团队科学 I2b2-整合生物学和床边的信息学加州大学洛杉矶分校 ICD-机构职业发展URM-在医学中的代表性不足 IIT-调查员发起的试验USC-南加州大学 IOB-内部监督委员会WD-员工发展核心小组 项目摘要/摘要页207 联系PD/PI：Buchanan，Thomas A UL1