ENDOCRINE DYSFUNCTION AND GROWTH HORMONE DEFICIENCY IN CHILDREN WITH ONH

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究的目的是研究诊断为视神经发育不良(ONH)的儿童的内分泌疾病。这项拟议的研究将首次专门评估大量ONH儿童的内分泌和生长结果，以及生长激素治疗对身体发育的影响。受试者将随机接受生长激素治疗和单纯观察(没有安慰剂对照)，并跟踪观察两年的生长结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to study endocrinopathies in children diagnosed with optic nerve hypoplasia (ONH). The proposed study will be the first to specifically evaluate a large number of ONH children for endocrinological and growth outcomes, and the impact of growth hormone treatment on physical development. Subjects will be randomized to treatment with growth hormone vs observation only (no placebo control) and followed for two years for growth outcomes.