ENDOCRINE DYSFUNCTION AND GROWTH HORMONE DEFICIENCY IN CHILDREN WITH ONH

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是研究诊断为视神经发育不全（ONH）的儿童的内分泌疾病。 这项拟议的研究将是第一个专门评估大量ONH儿童的内分泌和生长结果，以及生长激素治疗对身体发育的影响。受试者将随机接受生长激素治疗与仅观察治疗（无安慰剂对照），并随访两年以获得生长结局。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to study endocrinopathies in children diagnosed with optic nerve hypoplasia (ONH). The proposed study will be the first to specifically evaluate a large number of ONH children for endocrinological and growth outcomes, and the impact of growth hormone treatment on physical development. Subjects will be randomized to treatment with growth hormone vs observation only (no placebo control) and followed for two years for growth outcomes.